| Title |
Phenytoin intoxication associated with omeprazole administration in a child with defective CYP2C9
|
|---|---|
| Published in |
European Journal of Clinical Pharmacology, January 2020
|
| DOI | 10.1007/s00228-019-02821-y |
| Pubmed ID | |
| Authors |
M. Marano, F. Nicoletti, S. Pro, B. M. Goffredo, C. Cecchetti, E. Piervincenzi, E. Agolini, D. Cocciadiferro |
| Abstract |
Adverse drug reactions occur at a high rate in hospitalized children, frequently due to antiepileptic drug administration. Phenytoin is a commonly used drug, and its metabolism is mediated by a specific cytochrome-P450 isoform, CYP2C9, which is encoded by a polymorphic gene. It is worth noting that very frequently administered drugs, such as proton pump inhibitors, compete with phenytoin for CYP2C19-mediated metabolism. Here we describe a case of phenytoin intoxication in a child with defective CYP2C9, after omeprazole administration. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 13 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 2 | 15% |
| Student > Bachelor | 2 | 15% |
| Other | 1 | 8% |
| Student > Master | 1 | 8% |
| Unknown | 7 | 54% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 3 | 23% |
| Nursing and Health Professions | 1 | 8% |
| Chemistry | 1 | 8% |
| Neuroscience | 1 | 8% |
| Unknown | 7 | 54% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 January 2020.
All research outputs
#20,599,981
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Outputs from European Journal of Clinical Pharmacology
#2,406
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Outputs of similar age
#382,048
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Outputs of similar age from European Journal of Clinical Pharmacology
#28
of 32 outputs
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