| Title |
Microbial steroid transformations: current state and prospects
|
|---|---|
| Published in |
Applied Microbiology and Biotechnology, May 2012
|
| DOI | 10.1007/s00253-012-4078-0 |
| Pubmed ID | |
| Authors |
Marina V. Donova, Olga V. Egorova |
| Abstract |
Studies of steroid modifications catalyzed by microbial whole cells represent a well-established research area in white biotechnology. Still, advances over the last decade in genetic and metabolic engineering, whole-cell biocatalysis in non-conventional media, and process monitoring raised research in this field to a new level. This review summarizes the data on microbial steroid conversion obtained since 2003. The key reactions of structural steroid functionalization by microorganisms are highlighted including sterol side-chain degradation, hydroxylation at various positions of the steroid core, and redox reactions. We also describe methods for enhancement of bioprocess productivity, selectivity of target reactions, and application of microbial transformations for production of valuable pharmaceutical ingredients and precursors. Challenges and prospects of whole-cell biocatalysis applications in steroid industry are discussed. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 281 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 2 | <1% |
| Germany | 1 | <1% |
| Colombia | 1 | <1% |
| Spain | 1 | <1% |
| Japan | 1 | <1% |
| Unknown | 275 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 56 | 20% |
| Student > Bachelor | 47 | 17% |
| Researcher | 41 | 15% |
| Student > Master | 36 | 13% |
| Student > Postgraduate | 12 | 4% |
| Other | 35 | 12% |
| Unknown | 54 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 78 | 28% |
| Biochemistry, Genetics and Molecular Biology | 55 | 20% |
| Chemistry | 36 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 4% |
| Environmental Science | 9 | 3% |
| Other | 31 | 11% |
| Unknown | 62 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 September 2015.
All research outputs
#4,931,650
of 24,119,703 outputs
Outputs from Applied Microbiology and Biotechnology
#1,169
of 8,034 outputs
Outputs of similar age
#31,884
of 166,652 outputs
Outputs of similar age from Applied Microbiology and Biotechnology
#10
of 71 outputs
Altmetric has tracked 24,119,703 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,034 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done well, scoring higher than 85% of its peers.
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We're also able to compare this research output to 71 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.