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Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation

Overview of attention for article published in Nature, September 2007
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  • Above-average Attention Score compared to outputs of the same age (64th percentile)

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1 X user
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1 Wikipedia page

Citations

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311 Dimensions

Readers on

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337 Mendeley
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1 CiteULike
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5 Connotea
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Title
Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation
Published in
Nature, September 2007
DOI 10.1038/nature06160
Pubmed ID
Authors

Antonis Kirmizis, Helena Santos-Rosa, Christopher J. Penkett, Michael A. Singer, Michiel Vermeulen, Matthias Mann, Jürg Bähler, Roland D. Green, Tony Kouzarides

Abstract

Modifications on histones control important biological processes through their effects on chromatin structure. Methylation at lysine 4 on histone H3 (H3K4) is found at the 5' end of active genes and contributes to transcriptional activation by recruiting chromatin-remodelling enzymes. An adjacent arginine residue (H3R2) is also known to be asymmetrically dimethylated (H3R2me2a) in mammalian cells, but its location within genes and its function in transcription are unknown. Here we show that H3R2 is also methylated in budding yeast (Saccharomyces cerevisiae), and by using an antibody specific for H3R2me2a in a chromatin immunoprecipitation-on-chip analysis we determine the distribution of this modification on the entire yeast genome. We find that H3R2me2a is enriched throughout all heterochromatic loci and inactive euchromatic genes and is present at the 3' end of moderately transcribed genes. In all cases the pattern of H3R2 methylation is mutually exclusive with the trimethyl form of H3K4 (H3K4me3). We show that methylation at H3R2 abrogates the trimethylation of H3K4 by the Set1 methyltransferase. The specific effect on H3K4me3 results from the occlusion of Spp1, a Set1 methyltransferase subunit necessary for trimethylation. Thus, the inability of Spp1 to recognize H3 methylated at R2 prevents Set1 from trimethylating H3K4. These results provide the first mechanistic insight into the function of arginine methylation on chromatin.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 337 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 6 2%
Italy 3 <1%
United Kingdom 3 <1%
Japan 3 <1%
China 1 <1%
Belgium 1 <1%
Spain 1 <1%
Unknown 319 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 100 30%
Researcher 79 23%
Professor > Associate Professor 34 10%
Student > Master 20 6%
Student > Bachelor 17 5%
Other 53 16%
Unknown 34 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 189 56%
Biochemistry, Genetics and Molecular Biology 70 21%
Chemistry 14 4%
Medicine and Dentistry 10 3%
Immunology and Microbiology 5 1%
Other 12 4%
Unknown 37 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2019.
All research outputs
#7,170,757
of 22,665,794 outputs
Outputs from Nature
#64,658
of 90,603 outputs
Outputs of similar age
#24,485
of 71,222 outputs
Outputs of similar age from Nature
#375
of 504 outputs
Altmetric has tracked 22,665,794 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 90,603 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 99.2. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 71,222 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 504 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.