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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Association of Platelet Serotonin Levels in Alzheimer’s Disease with Clinical and Cerebrospinal Fluid Markers
|
|---|---|
| Published in |
Journal of Alzheimer's Disease, May 2016
|
| DOI | 10.3233/jad-160022 |
| Pubmed ID | |
| Authors |
Walid Tajeddinn, Seyed-Mohammad Fereshtehnejad, Mohammed Seed Ahmed, Takashi Yoshitake, Jan Kehr, Tasmin Shahnaz, Micha Milovanovic, Homira Behbahani, Kina Höglund, Bengt Winblad, Angel Cedazo-Minguez, Vesna Jelic, Petter Järemo, Dag Aarsland |
| Abstract |
Serotonin (5-HT) is involved in the pathology of Alzheimer's disease (AD). We aimed to measure 5-HT level in platelets in AD and explore its association with cerebrospinal fluid (CSF), AD biomarkers (amyloid-β 1-42 (Aβ42), total tau (t-tau), and phosphorylated tau (p-tau)), and clinical symptoms. 15 patients with AD and 20 patients with subjective cognitive impairment (SCI) were included. 5-HT metabolites were measured, in a specific fraction, using high performance liquid chromatography with electrochemical detection (HPLC-ECD). Significantly lower 5-HT concentrations were observed in AD patients compared to SCI patients both after normalization against total protein (p = 0.008) or platelet count (p = 0.019). SCI patients with lower 5-HT level have higher AD CSF biomarkers, total tau (p = 0.026) and tau/Aβ42 ratio (p = 0.001), compared to those with high 5-HT levels. AD patients have reduced platelets 5-HT levels. In SCI, lower 5-HT content was associated with a higher AD-CSF biomarker burden. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 42 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 19% |
| Student > Master | 5 | 12% |
| Student > Bachelor | 4 | 10% |
| Other | 4 | 10% |
| Professor | 3 | 7% |
| Other | 9 | 21% |
| Unknown | 9 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 24% |
| Psychology | 6 | 14% |
| Biochemistry, Genetics and Molecular Biology | 3 | 7% |
| Neuroscience | 3 | 7% |
| Agricultural and Biological Sciences | 2 | 5% |
| Other | 6 | 14% |
| Unknown | 12 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 January 2018.
All research outputs
#3,709,974
of 25,373,627 outputs
Outputs from Journal of Alzheimer's Disease
#2,896
of 7,452 outputs
Outputs of similar age
#57,329
of 312,451 outputs
Outputs of similar age from Journal of Alzheimer's Disease
#81
of 160 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,452 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.2. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 312,451 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 160 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.