| Title |
Different vascular permeability between the sensory and secretory circumventricular organs of adult mouse brain
|
|---|---|
| Published in |
Cell and Tissue Research, May 2012
|
| DOI | 10.1007/s00441-012-1421-9 |
| Pubmed ID | |
| Authors |
Shoko Morita, Seiji Miyata |
| Abstract |
The blood-brain barrier (BBB) prevents free access of circulating molecules to the brain and maintains a specialized brain environment to protect the brain from blood-derived bioactive and toxic molecules; however, the circumventricular organs (CVOs) have fenestrated vasculature. The fenestrated vasculature in the sensory CVOs, including the organum vasculosum of lamina terminalis (OVLT), subfornical organ (SFO) and area postrema (AP), allows neurons and astrocytes to sense a variety of plasma molecules and convey their information into other brain regions and the vasculature in the secretory CVOs, including median eminence (ME) and neurohypophysis (NH), permits neuronal terminals to secrete many peptides into the blood stream. The present study showed that vascular permeability of low-molecular-mass tracers such as fluorescein isothiocyanate (FITC) and Evans Blue was higher in the secretory CVOs and kidney as compared with that in the sensory CVOs. On the other hand, vascular permeability of high-molecular-mass tracers such as FITC-labeled bovine serum albumin and Dextran 70,000 was lower in the CVOs as compared with that in the kidney. Prominent vascular permeability of low- and high-molecular-mass tracers was also observed in the arcuate nucleus. These data demonstrate that vascular permeability for low-molecular-mass molecules is higher in the secretory CVOs as compared with that in the sensory CVOs, possibly for large secretion of peptides to the blood stream. Moreover, vascular permeability for high-molecular-mass tracers in the CVOs is smaller than that of the kidney, indicating that the CVOs are not totally without a BBB. |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 1% |
| Unknown | 78 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 23% |
| Researcher | 12 | 15% |
| Student > Bachelor | 10 | 13% |
| Student > Master | 8 | 10% |
| Student > Doctoral Student | 5 | 6% |
| Other | 15 | 19% |
| Unknown | 11 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 20 | 25% |
| Agricultural and Biological Sciences | 15 | 19% |
| Biochemistry, Genetics and Molecular Biology | 11 | 14% |
| Medicine and Dentistry | 8 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
| Other | 4 | 5% |
| Unknown | 17 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2022.
All research outputs
#8,187,876
of 24,541,341 outputs
Outputs from Cell and Tissue Research
#546
of 2,314 outputs
Outputs of similar age
#56,494
of 167,493 outputs
Outputs of similar age from Cell and Tissue Research
#10
of 34 outputs
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So far Altmetric has tracked 2,314 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
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We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.