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The landscape of cancer genes and mutational processes in breast cancer

Overview of attention for article published in Nature, May 2012
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

Mentioned by

news
2 news outlets
blogs
4 blogs
twitter
41 X users
patent
42 patents
facebook
1 Facebook page
wikipedia
2 Wikipedia pages
googleplus
2 Google+ users

Citations

dimensions_citation
1455 Dimensions

Readers on

mendeley
1612 Mendeley
citeulike
26 CiteULike
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Title
The landscape of cancer genes and mutational processes in breast cancer
Published in
Nature, May 2012
DOI 10.1038/nature11017
Pubmed ID
Authors

Philip J. Stephens, Patrick S. Tarpey, Helen Davies, Peter Van Loo, Chris Greenman, David C. Wedge, Serena Nik-Zainal, Sancha Martin, Ignacio Varela, Graham R. Bignell, Lucy R. Yates, Elli Papaemmanuil, David Beare, Adam Butler, Angela Cheverton, John Gamble, Jonathan Hinton, Mingming Jia, Alagu Jayakumar, David Jones, Calli Latimer, King Wai Lau, Stuart McLaren, David J. McBride, Andrew Menzies, Laura Mudie, Keiran Raine, Roland Rad, Michael Spencer Chapman, Jon Teague, Douglas Easton, Anita Langerød, Ming Ta Michael Lee, Chen-Yang Shen, Benita Tan Kiat Tee, Bernice Wong Huimin, Annegien Broeks, Ana Cristina Vargas, Gulisa Turashvili, John Martens, Aquila Fatima, Penelope Miron, Suet-Feung Chin, Gilles Thomas, Sandrine Boyault, Odette Mariani, Sunil R. Lakhani, Marc van de Vijver, Laura van ‘t Veer, John Foekens, Christine Desmedt, Christos Sotiriou, Andrew Tutt, Carlos Caldas, Jorge S. Reis-Filho, Samuel A. J. R. Aparicio, Anne Vincent Salomon, Anne-Lise Børresen-Dale, Andrea L. Richardson, Peter J. Campbell, P. Andrew Futreal, Michael R. Stratton

Abstract

All cancers carry somatic mutations in their genomes. A subset, known as driver mutations, confer clonal selective advantage on cancer cells and are causally implicated in oncogenesis, and the remainder are passenger mutations. The driver mutations and mutational processes operative in breast cancer have not yet been comprehensively explored. Here we examine the genomes of 100 tumours for somatic copy number changes and mutations in the coding exons of protein-coding genes. The number of somatic mutations varied markedly between individual tumours. We found strong correlations between mutation number, age at which cancer was diagnosed and cancer histological grade, and observed multiple mutational signatures, including one present in about ten per cent of tumours characterized by numerous mutations of cytosine at TpC dinucleotides. Driver mutations were identified in several new cancer genes including AKT2, ARID1B, CASP8, CDKN1B, MAP3K1, MAP3K13, NCOR1, SMARCD1 and TBX3. Among the 100 tumours, we found driver mutations in at least 40 cancer genes and 73 different combinations of mutated cancer genes. The results highlight the substantial genetic diversity underlying this common disease.

X Demographics

X Demographics

The data shown below were collected from the profiles of 41 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 1,612 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 33 2%
United Kingdom 18 1%
Germany 6 <1%
Canada 5 <1%
Netherlands 5 <1%
Spain 4 <1%
Denmark 4 <1%
France 3 <1%
China 3 <1%
Other 28 2%
Unknown 1503 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 404 25%
Student > Ph. D. Student 388 24%
Student > Master 161 10%
Student > Bachelor 106 7%
Student > Doctoral Student 79 5%
Other 271 17%
Unknown 203 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 610 38%
Biochemistry, Genetics and Molecular Biology 340 21%
Medicine and Dentistry 247 15%
Computer Science 47 3%
Chemistry 20 1%
Other 105 7%
Unknown 243 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 78. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 March 2024.
All research outputs
#544,621
of 25,380,089 outputs
Outputs from Nature
#23,690
of 97,721 outputs
Outputs of similar age
#2,536
of 176,055 outputs
Outputs of similar age from Nature
#270
of 973 outputs
Altmetric has tracked 25,380,089 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 97,721 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 102.3. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 176,055 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 973 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.