Title |
Immunogenetic contributions to recurrent pregnancy loss
|
---|---|
Published in |
Journal of Assisted Reproduction and Genetics, May 2016
|
DOI | 10.1007/s10815-016-0720-6 |
Pubmed ID | |
Authors |
Frances Grimstad, Sacha Krieg |
Abstract |
While sporadic pregnancy loss is common, occurring in 15 % of pregnancies, recurrent pregnancy loss (RPL) impacts approximately 5 % of couples. Though multiple causes are known (including structural, hormonal, infectious, autoimmune, and thrombophilic causes), after evaluation, roughly half of all cases remain unexplained. The idiopathic RPL cases pose a challenging therapeutic dilemma in addition to incurring much physical and emotional morbidity. Immunogenetic causes have been postulated to contribute to these cases of RPL. Natural Killer cell, T cell expression pattern changes in the endometrium have both been shown in patients with RPL. Human leukocyte antigen (HLA) and cytokine allelic variations have also been studied as etiologies for RPL. Some of the results have been promising, however the studies are small and have not yet put forth outcomes that would change our current diagnosis and management of RPL. Larger database studies are needed with stricter control criteria before reasonable conclusions can be drawn. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Venezuela, Bolivarian Republic of | 4 | 50% |
Unknown | 4 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 75% |
Scientists | 2 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 75 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 15% |
Student > Ph. D. Student | 10 | 13% |
Student > Master | 9 | 12% |
Student > Bachelor | 7 | 9% |
Student > Doctoral Student | 6 | 8% |
Other | 12 | 16% |
Unknown | 20 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 25 | 33% |
Biochemistry, Genetics and Molecular Biology | 13 | 17% |
Immunology and Microbiology | 6 | 8% |
Agricultural and Biological Sciences | 4 | 5% |
Veterinary Science and Veterinary Medicine | 1 | 1% |
Other | 2 | 3% |
Unknown | 24 | 32% |