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Multiparameter analysis of naevi and primary melanomas identifies a subset of naevi with elevated markers of transformation

Overview of attention for article published in Pigment Cell & Melanoma Research, June 2016
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  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

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3 X users

Citations

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Title
Multiparameter analysis of naevi and primary melanomas identifies a subset of naevi with elevated markers of transformation
Published in
Pigment Cell & Melanoma Research, June 2016
DOI 10.1111/pcmr.12489
Pubmed ID
Authors

Carly Fox, Duncan Lambie, James S Wilmott, Alex Pinder, Sandra Pavey, Kim-Anh Lê Cao, Taner Akalin, Isil Kilinc Karaarslan, Fezal Ozdemir, Richard A Scolyer, Miko Yamada, H Peter Soyer, Helmut Schaider, Brian Gabrielli

Abstract

Here we have carried out a multiparameter analysis using a panel of 28 immunohistochemical markers to identify markers of transformation from benign and dysplastic naevus to primary melanoma in three separate cohorts totaling 279 lesions. We have identified a set of eight markers that distinguish naevi from melanoma. None of markers or parameters assessed differentiated benign from dysplastic naevi. Indeed, the naevi clustered tightly in terms of their immunostaining patterns whereas primary melanomas showed more diverse staining patterns. A small subset of histopathologically benign lesions had elevated levels of multiple markers associated with melanoma, suggesting that these represent naevi with an increased potential for transformation to melanoma. This article is protected by copyright. All rights reserved.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Other 2 22%
Student > Ph. D. Student 2 22%
Professor 1 11%
Student > Master 1 11%
Researcher 1 11%
Other 0 0%
Unknown 2 22%
Readers by discipline Count As %
Medicine and Dentistry 3 33%
Agricultural and Biological Sciences 3 33%
Biochemistry, Genetics and Molecular Biology 1 11%
Unknown 2 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 May 2016.
All research outputs
#15,443,937
of 24,484,013 outputs
Outputs from Pigment Cell & Melanoma Research
#446
of 932 outputs
Outputs of similar age
#210,315
of 360,969 outputs
Outputs of similar age from Pigment Cell & Melanoma Research
#4
of 16 outputs
Altmetric has tracked 24,484,013 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 932 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 360,969 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.