| Title |
Adherence to Antiretroviral Therapy and Acceptability of Planned Treatment Interruptions in HIV-Infected Children
|
|---|---|
| Published in |
AIDS and Behavior, May 2012
|
| DOI | 10.1007/s10461-012-0197-y |
| Pubmed ID | |
| Authors |
Linda Harrison, Jintanat Ananworanich, Djamel Hamadache, Alexandra Compagnucci, Martina Penazzato, Torsak Bunupuradah, Antonio Mazza, Jose Tomas Ramos, Jacquie Flynn, Osvalda Rampon, Maria Jose Mellado Pena, Daniel Floret, Magdalena Marczynska, Ana Puga, Silvia Forcat, Yoann Riault, Marc Lallemant, Hannah Castro, Diana M. Gibb, Carlo Giaquinto, On Behalf of the Paediatric European Network for Treatment of AIDS (PENTA) 11 Trial Team |
| Abstract |
There have been no paediatric randomised trials describing the effect of planned treatment interruptions (PTIs) of antiretroviral therapy (ART) on adherence, or evaluating acceptability of such a strategy. In PENTA 11, HIV-infected children were randomised to CD4-guided PTIs (n = 53) or continuous therapy (CT, n = 56). Carers, and children if appropriate, completed questionnaires on adherence to ART and acceptability of PTIs. There was no difference in reported adherence on ART between CT and PTI groups; non-adherence (reporting missed doses over the last 3 days or marking <100 % adherence since the last clinical visit on a visual analogue scale) was 18 % (20/111) and 14 % (12/83) on carer questionnaires in the CT and PTI groups respectively (odds ratios, OR (95 % CI) = 1.04 (0.20, 5.41), χ(2) (1) = 0.003, p = 0.96). Carers in Europe/USA reported non-adherence more often (31/121, 26 %) than in Thailand (1/73, 1 %; OR (95 % CI) = 54.65 (3.68, 810.55), χ(2) (1) = 8.45, p = 0.004). The majority of families indicated they were happy to have further PTIs (carer: 23/36, 64 %; children: 8/13, 62 %), however many reported more clinic visits during PTI were a problem (carer: 15/36, 42 %; children: 6/12, 50 %). |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 33% |
| Kenya | 1 | 33% |
| United States | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ethiopia | 2 | 2% |
| Burkina Faso | 1 | <1% |
| India | 1 | <1% |
| United Kingdom | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 96 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 16 | 16% |
| Researcher | 15 | 15% |
| Student > Doctoral Student | 10 | 10% |
| Student > Bachelor | 9 | 9% |
| Other | 7 | 7% |
| Other | 25 | 25% |
| Unknown | 20 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 36 | 35% |
| Psychology | 10 | 10% |
| Nursing and Health Professions | 8 | 8% |
| Social Sciences | 4 | 4% |
| Business, Management and Accounting | 3 | 3% |
| Other | 16 | 16% |
| Unknown | 25 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2016.
All research outputs
#7,866,480
of 23,849,058 outputs
Outputs from AIDS and Behavior
#1,389
of 3,566 outputs
Outputs of similar age
#55,527
of 165,721 outputs
Outputs of similar age from AIDS and Behavior
#19
of 49 outputs
Altmetric has tracked 23,849,058 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,566 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 165,721 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.