| Title |
Neuroprotection in Diabetic Retinopathy
|
|---|---|
| Published in |
Current Diabetes Reports, May 2012
|
| DOI | 10.1007/s11892-012-0284-5 |
| Pubmed ID | |
| Authors |
Cristina Hernández, Rafael Simó |
| Abstract |
Diabetic retinopathy (DR) has been considered to be a microcirculatory disease of the retina. However, there is emerging evidence to suggest that retinal neurodegeneration is an early event in the pathogenesis of DR, which may antedate, and also participates in, the microcirculatory abnormalities that occur in DR. Therefore, the study of the underlying mechanisms that lead to neurodegeneration will be essential for identifying new therapeutic targets in the early stages of DR. Elevated levels of glutamate, oxidative stress, the overexpression of the renin-angiotensin system and the upregulation of RAGE play an essential role in the retinal neurodegeneration induced by diabetes. Finally, the balance between the neurotoxic and neuroprotective factors is crucial in determining the survival of retinal neurons. In this review we will focus on neurotrophic factors already synthesized by the retina in physiological conditions as a new therapy strategy for neuroprotection. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 2 | 3% |
| Mexico | 1 | 2% |
| Germany | 1 | 2% |
| Canada | 1 | 2% |
| Unknown | 59 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 19% |
| Researcher | 12 | 19% |
| Student > Master | 10 | 16% |
| Student > Bachelor | 7 | 11% |
| Student > Doctoral Student | 4 | 6% |
| Other | 15 | 23% |
| Unknown | 4 | 6% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 30% |
| Agricultural and Biological Sciences | 11 | 17% |
| Biochemistry, Genetics and Molecular Biology | 10 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 14% |
| Neuroscience | 4 | 6% |
| Other | 7 | 11% |
| Unknown | 4 | 6% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2017.
All research outputs
#6,912,149
of 22,665,794 outputs
Outputs from Current Diabetes Reports
#341
of 1,005 outputs
Outputs of similar age
#48,678
of 163,463 outputs
Outputs of similar age from Current Diabetes Reports
#7
of 14 outputs
Altmetric has tracked 22,665,794 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 1,005 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 163,463 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.