| Title |
Clinical significance of microRNAs in chronic and acute human leukemia
|
|---|---|
| Published in |
Molecular Cancer, May 2016
|
| DOI | 10.1186/s12943-016-0518-2 |
| Pubmed ID | |
| Authors |
Chien-Hung Yeh, Ramona Moles, Christophe Nicot |
| Abstract |
Small non-coding microRNAs (miRNAs) are epigenetic regulators that target specific cellular mRNA to modulate gene expression patterns and cellular signaling pathways. miRNAs are involved in a wide range of biological processes and are frequently deregulated in human cancers. Numerous miRNAs promote tumorigenesis and cancer progression by enhancing tumor growth, angiogenesis, invasion and immune evasion, while others have tumor suppressive effects (Hayes, et al., Trends Mol Med 20(8): 460-9, 2014; Stahlhut and Slack, Genome Med 5 (12): 111, 2013). The expression profile of cancer miRNAs can be used to predict patient prognosis and clinical response to treatment (Bouchie, Nat Biotechnol 31(7): 577, 2013). The majority of miRNAs are intracellular localized, however circulating miRNAs have been detected in various body fluids and represent new biomarkers of solid and hematologic cancers (Fabris and Calin, Mol Oncol 10(3):503-8, 2016; Allegra, et al., Int J Oncol 41(6): 1897-912, 2012). This review describes the clinical relevance of miRNAs, lncRNAs and snoRNAs in the diagnosis, prognosis and treatment response in patients with chronic lymphocytic leukemia (CLL), chronic myeloid leukemia (CML), acute lymphocytic leukemia (ALL), acute myeloid leukemia (AML) and acute adult T-cell leukemia (ATL). |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 126 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | <1% |
| Unknown | 125 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 20 | 16% |
| Student > Bachelor | 19 | 15% |
| Student > Ph. D. Student | 15 | 12% |
| Researcher | 13 | 10% |
| Student > Postgraduate | 8 | 6% |
| Other | 18 | 14% |
| Unknown | 33 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 41 | 33% |
| Medicine and Dentistry | 18 | 14% |
| Agricultural and Biological Sciences | 12 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 6% |
| Computer Science | 3 | 2% |
| Other | 9 | 7% |
| Unknown | 36 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2016.
All research outputs
#18,458,033
of 22,870,727 outputs
Outputs from Molecular Cancer
#1,294
of 1,724 outputs
Outputs of similar age
#231,958
of 313,736 outputs
Outputs of similar age from Molecular Cancer
#16
of 24 outputs
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