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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Lysogeny with Shiga Toxin 2-Encoding Bacteriophages Represses Type III Secretion in Enterohemorrhagic Escherichia coli
|
|---|---|
| Published in |
PLoS Pathogens, May 2012
|
| DOI | 10.1371/journal.ppat.1002672 |
| Pubmed ID | |
| Authors |
Xuefang Xu, Sean P. McAteer, Jai J. Tree, Darren J. Shaw, Eliza B. K. Wolfson, Scott A. Beatson, Andrew J. Roe, Lesley J. Allison, Margo E. Chase-Topping, Arvind Mahajan, Rosangela Tozzoli, Mark E. J. Woolhouse, Stefano Morabito, David L. Gally |
| Abstract |
Lytic or lysogenic infections by bacteriophages drive the evolution of enteric bacteria. Enterohemorrhagic Escherichia coli (EHEC) have recently emerged as a significant zoonotic infection of humans with the main serotypes carried by ruminants. Typical EHEC strains are defined by the expression of a type III secretion (T3S) system, the production of Shiga toxins (Stx) and association with specific clinical symptoms. The genes for Stx are present on lambdoid bacteriophages integrated into the E. coli genome. Phage type (PT) 21/28 is the most prevalent strain type linked with human EHEC infections in the United Kingdom and is more likely to be associated with cattle shedding high levels of the organism than PT32 strains. In this study we have demonstrated that the majority (90%) of PT 21/28 strains contain both Stx2 and Stx2c phages, irrespective of source. This is in contrast to PT 32 strains for which only a minority of strains contain both Stx2 and 2c phages (28%). PT21/28 strains had a lower median level of T3S compared to PT32 strains and so the relationship between Stx phage lysogeny and T3S was investigated. Deletion of Stx2 phages from EHEC strains increased the level of T3S whereas lysogeny decreased T3S. This regulation was confirmed in an E. coli K12 background transduced with a marked Stx2 phage followed by measurement of a T3S reporter controlled by induced levels of the LEE-encoded regulator (Ler). The presence of an integrated Stx2 phage was shown to repress Ler induction of LEE1 and this regulation involved the CII phage regulator. This repression could be relieved by ectopic expression of a cognate CI regulator. A model is proposed in which Stx2-encoding bacteriophages regulate T3S to co-ordinate epithelial cell colonisation that is promoted by Stx and secreted effector proteins. |
X Demographics
The data shown below were collected from the profiles of 22 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 18% |
| United States | 3 | 14% |
| Australia | 2 | 9% |
| Spain | 1 | 5% |
| Ireland | 1 | 5% |
| Curaçao | 1 | 5% |
| Egypt | 1 | 5% |
| Switzerland | 1 | 5% |
| Unknown | 8 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 14 | 64% |
| Members of the public | 8 | 36% |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 2% |
| United States | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 97 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 23 | 23% |
| Student > Ph. D. Student | 16 | 16% |
| Student > Bachelor | 15 | 15% |
| Student > Master | 13 | 13% |
| Professor > Associate Professor | 7 | 7% |
| Other | 20 | 20% |
| Unknown | 7 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 44 | 44% |
| Immunology and Microbiology | 20 | 20% |
| Biochemistry, Genetics and Molecular Biology | 15 | 15% |
| Chemistry | 3 | 3% |
| Veterinary Science and Veterinary Medicine | 3 | 3% |
| Other | 7 | 7% |
| Unknown | 9 | 9% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 December 2023.
All research outputs
#2,483,177
of 25,477,125 outputs
Outputs from PLoS Pathogens
#2,351
of 9,486 outputs
Outputs of similar age
#15,104
of 176,955 outputs
Outputs of similar age from PLoS Pathogens
#25
of 146 outputs
Altmetric has tracked 25,477,125 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,486 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.3. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 176,955 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 146 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.