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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Gene Deregulation and Chronic Activation in Natural Killer Cells Deficient in the Transcription Factor ETS1
|
|---|---|
| Published in |
Immunity, May 2012
|
| DOI | 10.1016/j.immuni.2012.04.006 |
| Pubmed ID | |
| Authors |
Kevin Ramirez, Katherine J. Chandler, Christina Spaulding, Sasan Zandi, Mikael Sigvardsson, Barbara J. Graves, Barbara L. Kee |
| Abstract |
Multiple transcription factors guide the development of mature functional natural killer (NK) cells, yet little is known about their function. We used global gene expression and genome-wide binding analyses combined with developmental and functional studies to unveil three roles for the ETS1 transcription factor in NK cells. ETS1 functions at the earliest stages of NK cell development to promote expression of critical transcriptional regulators including T-BET and ID2, NK cell receptors (NKRs) including NKp46, Ly49H, and Ly49D, and signaling molecules essential for NKR function. As a consequence, Ets1(-/-) NK cells fail to degranulate after stimulation through activating NKRs. Nonetheless, these cells are hyperresponsive to cytokines and have characteristics of chronic stimulation including increased expression of inhibitory NKRs and multiple activation-associated genes. Therefore, ETS1 regulates a broad gene expression program in NK cells that promotes target cell recognition while limiting cytokine-driven activation. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 33% |
| Spain | 1 | 33% |
| United States | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 3 | 4% |
| Italy | 1 | 1% |
| Unknown | 74 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 35% |
| Researcher | 13 | 17% |
| Student > Doctoral Student | 7 | 9% |
| Student > Master | 7 | 9% |
| Student > Bachelor | 4 | 5% |
| Other | 7 | 9% |
| Unknown | 13 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 23 | 29% |
| Immunology and Microbiology | 23 | 29% |
| Biochemistry, Genetics and Molecular Biology | 10 | 13% |
| Medicine and Dentistry | 6 | 8% |
| Computer Science | 1 | 1% |
| Other | 2 | 3% |
| Unknown | 13 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 May 2012.
All research outputs
#15,091,901
of 25,374,647 outputs
Outputs from Immunity
#4,272
of 4,816 outputs
Outputs of similar age
#101,663
of 176,744 outputs
Outputs of similar age from Immunity
#35
of 51 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,816 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.3. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 176,744 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.