Title |
The ticking time bomb: escalating antibiotic resistance in Neisseria gonorrhoeae is a public health disaster in waiting
|
---|---|
Published in |
Journal of Antimicrobial Chemotherapy (JAC), May 2012
|
DOI | 10.1093/jac/dks188 |
Pubmed ID | |
Authors |
David M. Whiley, Namraj Goire, Monica M. Lahra, Basil Donovan, Athena E. Limnios, Michael D. Nissen, Theo P. Sloots |
Abstract |
From a once easily treatable infection, gonorrhoea has evolved into a challenging disease, which in future may become untreatable in certain circumstances. International spread of extensively drug-resistant gonococci would have severe public health implications. It seems clear that under the current treatment pressure from extended-spectrum cephalosporins, and owing to Neisseria gonorrhoeae's remarkable evolutionary adaptability, further rise of ceftriaxone-resistant strains around the world is inevitable. Simply increasing the doses of extended-spectrum cephalosporins will likely prove ineffective in the long run, and has been a lesson learnt for all single-agent therapies used for gonorrhoea to date. We recommend that dual therapy, especially those consisting of extended-spectrum cephalosporins and azithromycin, be adopted more widely and complemented by strengthening of antimicrobial resistance surveillance. Unless there is urgent action at international and local levels to combat the problem of N. gonorrhoeae antimicrobial resistance, we are in for gloomy times ahead in terms of gonorrhoea disease and control. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 4 | 19% |
Spain | 3 | 14% |
United States | 2 | 10% |
South Africa | 1 | 5% |
Micronesia, Federated States of | 1 | 5% |
Singapore | 1 | 5% |
Unknown | 9 | 43% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 17 | 81% |
Practitioners (doctors, other healthcare professionals) | 2 | 10% |
Scientists | 1 | 5% |
Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 3% |
United Kingdom | 1 | 1% |
Chile | 1 | 1% |
Netherlands | 1 | 1% |
Unknown | 93 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 18 | 18% |
Researcher | 16 | 16% |
Other | 13 | 13% |
Student > Ph. D. Student | 11 | 11% |
Student > Postgraduate | 8 | 8% |
Other | 20 | 20% |
Unknown | 13 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 28 | 28% |
Agricultural and Biological Sciences | 16 | 16% |
Biochemistry, Genetics and Molecular Biology | 13 | 13% |
Immunology and Microbiology | 6 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
Other | 17 | 17% |
Unknown | 15 | 15% |