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Attention Score in Context
| Title |
Side-Chain Interactions Form Late and Cooperatively in the Binding Reaction between Disordered Peptides and PDZ Domains
|
|---|---|
| Published in |
Journal of the American Chemical Society, December 2011
|
| DOI | 10.1021/ja209341w |
| Pubmed ID | |
| Authors |
S. Raza Haq, Celestine N. Chi, Anders Bach, Jakob Dogan, Åke Engström, Greta Hultqvist, O. Andreas Karlsson, Patrik Lundström, Linda C. Montemiglio, Kristian Strømgaard, Stefano Gianni, Per Jemth |
| Abstract |
Intrinsically disordered proteins are very common and mediate numerous protein-protein and protein-DNA interactions. While it is clear that these interactions are instrumental for the life of the mammalian cell, there is a paucity of data regarding their molecular binding mechanisms. Here we have used short peptides as a model system for intrinsically disordered proteins. Linear free energy relationships based on rate and equilibrium constants for the binding of these peptides to ordered target proteins, PDZ domains, demonstrate that native side-chain interactions form mainly after the rate-limiting barrier for binding and in a cooperative fashion. This finding suggests that these disordered peptides first form a weak encounter complex with non-native interactions. The data do not support the recent notion that the affinities of intrinsically disordered proteins toward their targets are generally governed by their association rate constants. Instead, we observed the opposite for peptide-PDZ interactions, namely, that changes in K(d) correlate with changes in k(off). |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Italy | 1 | 2% |
| Korea, Republic of | 1 | 2% |
| Canada | 1 | 2% |
| United Kingdom | 1 | 2% |
| Unknown | 58 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 33% |
| Researcher | 10 | 16% |
| Student > Master | 6 | 9% |
| Student > Bachelor | 4 | 6% |
| Professor > Associate Professor | 4 | 6% |
| Other | 9 | 14% |
| Unknown | 10 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 17 | 27% |
| Chemistry | 17 | 27% |
| Biochemistry, Genetics and Molecular Biology | 15 | 23% |
| Arts and Humanities | 1 | 2% |
| Physics and Astronomy | 1 | 2% |
| Other | 3 | 5% |
| Unknown | 10 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 January 2022.
All research outputs
#4,606,084
of 22,818,766 outputs
Outputs from Journal of the American Chemical Society
#16,050
of 61,996 outputs
Outputs of similar age
#39,564
of 241,954 outputs
Outputs of similar age from Journal of the American Chemical Society
#188
of 482 outputs
Altmetric has tracked 22,818,766 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 61,996 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,954 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 482 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.