| Title |
Twenty year fitness trends in young adults and incidence of prediabetes and diabetes: the CARDIA study
|
|---|---|
| Published in |
Diabetologia, May 2016
|
| DOI | 10.1007/s00125-016-3969-5 |
| Pubmed ID | |
| Authors |
Lisa S. Chow, Andrew O. Odegaard, Tyler A. Bosch, Anne E. Bantle, Qi Wang, John Hughes, Mercedes Carnethon, Katherine H. Ingram, Nefertiti Durant, Cora E. Lewis, Justin Ryder, Christina M. Shay, Aaron S. Kelly, Pamela J. Schreiner |
| Abstract |
The prospective association between cardiorespiratory fitness (CRF) measured in young adulthood and middle age on development of prediabetes, defined as impaired fasting glucose and/or impaired glucose tolerance, or diabetes by middle age remains unknown. We hypothesised that higher fitness levels would be associated with reduced risk for developing incident prediabetes/diabetes by middle age. Participants were from the Coronary Artery Risk Development in Young Adults (CARDIA) study who were free from prediabetes/diabetes at baseline (year 0 [Y0]: 1985-1986). CRF was quantified by treadmill duration (converted to metabolic equivalents [METs]) at Y0, Y7 and Y20 and prediabetes/diabetes status was assessed at Y0, Y7, Y10, Y15, Y20 and Y25. We use an extended Cox model with CRF as the primary time-varying exposure. BMI was included as a time-varying covariate. The outcome was development of either prediabetes or diabetes after Y0. Model 1 included age, race, sex, field centre, CRF and BMI. Model 2 additionally included baseline (Y0) smoking, energy intake, alcohol intake, education, systolic BP, BP medication use and lipid profile. Higher fitness was associated with lower risk for developing incident prediabetes/diabetes (difference of 1 MET: HR 0.99898 [95% CI 0.99861, 0.99940], p < 0.01), which persisted (difference of 1 MET: HR 0.99872 [95% CI 0.99840, 0.99904], p < 0.01] when adjusting for covariates. Examining participants who had fitness measured from young adulthood to middle age, we found that fitness was associated with lower risk for developing prediabetes/diabetes, even when adjusting for BMI over this time period. These findings emphasise the importance of fitness in reducing the health burden of prediabetes and diabetes. |
X Demographics
The data shown below were collected from the profiles of 67 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 11 | 16% |
| United Kingdom | 9 | 13% |
| Spain | 6 | 9% |
| Canada | 6 | 9% |
| Luxembourg | 2 | 3% |
| Netherlands | 2 | 3% |
| Venezuela, Bolivarian Republic of | 2 | 3% |
| Australia | 2 | 3% |
| Denmark | 1 | 1% |
| Other | 7 | 10% |
| Unknown | 19 | 28% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 36 | 54% |
| Scientists | 20 | 30% |
| Practitioners (doctors, other healthcare professionals) | 10 | 15% |
| Science communicators (journalists, bloggers, editors) | 1 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | 2% |
| Unknown | 86 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 13 | 15% |
| Researcher | 12 | 14% |
| Student > Bachelor | 12 | 14% |
| Student > Ph. D. Student | 11 | 13% |
| Other | 5 | 6% |
| Other | 12 | 14% |
| Unknown | 23 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 29 | 33% |
| Nursing and Health Professions | 8 | 9% |
| Agricultural and Biological Sciences | 4 | 5% |
| Sports and Recreations | 4 | 5% |
| Social Sciences | 2 | 2% |
| Other | 8 | 9% |
| Unknown | 33 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 700. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 February 2018.
All research outputs
#28,846
of 25,081,505 outputs
Outputs from Diabetologia
#26
of 5,337 outputs
Outputs of similar age
#542
of 330,877 outputs
Outputs of similar age from Diabetologia
#3
of 94 outputs
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