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Exosome‐encapsulated microRNAs as circulating biomarkers for breast cancer

Overview of attention for article published in International Journal of Cancer, May 2016
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  • Good Attention Score compared to outputs of the same age (67th percentile)
  • Good Attention Score compared to outputs of the same age and source (68th percentile)

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1 patent

Citations

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158 Dimensions

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Title
Exosome‐encapsulated microRNAs as circulating biomarkers for breast cancer
Published in
International Journal of Cancer, May 2016
DOI 10.1002/ijc.30179
Pubmed ID
Authors

Doireann P Joyce, Michael J Kerin, Róisín M Dwyer

Abstract

Breast cancer is a highly prevalent disease, accounting for 29% of invasive cancers in women. Survival from this disease depends on the stage at diagnosis, with patients who are detected earlier having more favourable outcomes. It is because of this that research groups are focusing on the development of a blood-based biomarker for breast cancer. Such biomarkers may facilitate the detection of breast cancer in its infancy before it has spread beyond the primary site. MicroRNAs (miRNA) have shown immense potential in this setting. These short, non-coding RNA sequences have been shown to be dysregulated in breast cancer. Despite showing immense promise, miRNAs have not been successfully implemented in the clinical setting due to a lack of a standardised approach which has resulted in conflicting results. These challenges may be addressed at least in part through the study of exosomes. The biomarker potential for exosomes holds huge promise and may revolutionise the way in which we diagnose and manage breast cancer. These nanovesicles may be isolated from a variety of bodily fluids, including serum, and their miRNA content has been shown to reflect that of the parent breast cancer cell. This review will highlight the nomenclature and defining characteristics of exosomes, and current methods of isolation of serum-derived exosomes. Initial promising reports on the potential utility of exosomal miRNAs to be used as breast cancer biomarkers will also be addressed. This article is protected by copyright. All rights reserved.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 182 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 <1%
Argentina 1 <1%
Unknown 180 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 40 22%
Researcher 25 14%
Student > Master 17 9%
Student > Bachelor 14 8%
Student > Doctoral Student 13 7%
Other 21 12%
Unknown 52 29%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 42 23%
Medicine and Dentistry 24 13%
Agricultural and Biological Sciences 22 12%
Engineering 10 5%
Pharmacology, Toxicology and Pharmaceutical Science 6 3%
Other 17 9%
Unknown 61 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2022.
All research outputs
#7,036,153
of 24,484,013 outputs
Outputs from International Journal of Cancer
#4,359
of 12,084 outputs
Outputs of similar age
#107,340
of 345,438 outputs
Outputs of similar age from International Journal of Cancer
#28
of 95 outputs
Altmetric has tracked 24,484,013 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 12,084 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 345,438 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.