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Adenovector GAD65 Gene Delivery into the Rat Trigeminal Ganglion Produces Orofacial Analgesia

Overview of attention for article published in Molecular Pain, January 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

Mentioned by

blogs
1 blog
patent
1 patent

Citations

dimensions_citation
48 Dimensions

Readers on

mendeley
38 Mendeley
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Title
Adenovector GAD65 Gene Delivery into the Rat Trigeminal Ganglion Produces Orofacial Analgesia
Published in
Molecular Pain, January 2009
DOI 10.1186/1744-8069-5-42
Pubmed ID
Authors

Jean-Philippe Vit, Peter T Ohara, Christopher Sundberg, Blanca Rubi, Pierre Maechler, Chunyan Liu, Mariana Puntel, Pedro Lowenstein, Maria Castro, Luc Jasmin

Abstract

Our goal is to use gene therapy to alleviate pain by targeting glial cells. In an animal model of facial pain we tested the effect of transfecting the glutamic acid decarboxylase (GAD) gene into satellite glial cells (SGCs) of the trigeminal ganglion by using a serotype 5 adenovector with high tropisms for glial cells. We postulated that GABA produced from the expression of GAD would reduce pain behavior by acting on GABA receptors on neurons within the ganglion.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Czechia 1 3%
Ireland 1 3%
Austria 1 3%
Unknown 34 89%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 24%
Student > Ph. D. Student 7 18%
Student > Bachelor 3 8%
Professor 3 8%
Student > Master 3 8%
Other 6 16%
Unknown 7 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 34%
Medicine and Dentistry 7 18%
Neuroscience 5 13%
Biochemistry, Genetics and Molecular Biology 1 3%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 2 5%
Unknown 9 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 April 2019.
All research outputs
#4,082,192
of 25,374,647 outputs
Outputs from Molecular Pain
#73
of 669 outputs
Outputs of similar age
#22,255
of 183,281 outputs
Outputs of similar age from Molecular Pain
#5
of 24 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 669 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 183,281 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.