Title |
Positron emission tomography changes management, improves prognostic stratification and is superior to gallium scintigraphy in patients with low-grade lymphoma: results of a multicentre prospective study
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Published in |
European Journal of Nuclear Medicine and Molecular Imaging, October 2008
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DOI | 10.1007/s00259-008-0958-z |
Pubmed ID | |
Authors |
Andrew M. Scott, Dishan H. Gunawardana, Joseph Wong, Ian Kirkwood, Rodney J. Hicks, Ivan Ho Shon, Jayne E. Ramshaw, Peter Robins |
Abstract |
Positron emission tomography (PET) was evaluated in low-grade non-Hodgkin lymphoma (NHL) to determine its impact on staging and management and to compare PET and gallium scans. PET resulted in management plan changes in 74 patients with untreated low-grade NHL stages I to III. Patient outcomes to 12 months were documented. PET identified additional lesions in 50% of patients, led to a change in stage in 32%, and had a significant impact on management in 34%. Inferior progression-free survival was noted in patients with additional lesions detected by PET (p=0.001) and in the 28% of patients upstaged by PET to stage III or IV (p=0.024). In a subset of 16 patients undergoing both PET and gallium scans, PET was found to be superior. PET has a major role in the management of low-grade NHL in addition to its proven role in aggressive lymphoma. |
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Geographical breakdown
Country | Count | As % |
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Spain | 1 | 5% |
Canada | 1 | 5% |
Unknown | 19 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 5 | 24% |
Other | 3 | 14% |
Professor > Associate Professor | 3 | 14% |
Professor | 2 | 10% |
Student > Doctoral Student | 2 | 10% |
Other | 3 | 14% |
Unknown | 3 | 14% |
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Unknown | 3 | 14% |