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Mendeley readers
Attention Score in Context
| Title |
The Rac2 Guanosine Triphosphatase Regulates B Lymphocyte Antigen Receptor Responses and Chemotaxis and Is Required for Establishment of B-1a and Marginal Zone B Lymphocytes
|
|---|---|
| Published in |
The Journal of Immunology, April 2002
|
| DOI | 10.4049/jimmunol.168.7.3376 |
| Pubmed ID | |
| Authors |
Ben A. Croker, David M. Tarlinton, Leonie A. Cluse, Alana J. Tuxen, Amanda Light, Feng-Chun Yang, David A. Williams, Andrew W. Roberts |
| Abstract |
We have defined roles for the hemopoietic-specific Rho guanosine triphosphatase, Rac2, in B lymphocyte development and function through examination of rac2(-/-) mice. Rac2-deficient mice displayed peripheral blood B lymphocytosis and marked reductions in peritoneal cavity B-1a lymphocytes, marginal zone B lymphocytes, and IgM-secreting plasma cells as well as reduced concentrations of serum IgM and IgA. The rac2(-/-) B lymphocytes exhibited reduced calcium flux following coligation of B cell AgR and CD19 and reduced chemotaxis in chemokine gradients. T cell-independent responses to DNP-dextran were of reduced magnitude, but normal kinetics, in rac2(-/-) mice, while T-dependent responses to nitrophenyl-keyhole limpet hemocyanin were subtly abnormal. Rac2 is therefore an essential element in regulating B lymphocyte functions and maintaining B lymphocyte populations in vivo. |
Mendeley readers
The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Korea, Republic of | 1 | 2% |
| United States | 1 | 2% |
| Unknown | 41 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 30% |
| Student > Ph. D. Student | 10 | 23% |
| Professor | 3 | 7% |
| Student > Doctoral Student | 2 | 5% |
| Lecturer > Senior Lecturer | 2 | 5% |
| Other | 5 | 12% |
| Unknown | 8 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 37% |
| Immunology and Microbiology | 8 | 19% |
| Biochemistry, Genetics and Molecular Biology | 4 | 9% |
| Medicine and Dentistry | 4 | 9% |
| Economics, Econometrics and Finance | 1 | 2% |
| Other | 3 | 7% |
| Unknown | 7 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2016.
All research outputs
#7,481,847
of 22,870,727 outputs
Outputs from The Journal of Immunology
#7,942
of 19,793 outputs
Outputs of similar age
#39,956
of 121,602 outputs
Outputs of similar age from The Journal of Immunology
#107
of 247 outputs
Altmetric has tracked 22,870,727 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 19,793 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 121,602 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 247 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.