| Title |
The third dimension: new developments in cell culture models for colorectal research
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, May 2016
|
| DOI | 10.1007/s00018-016-2258-2 |
| Pubmed ID | |
| Authors |
Joana F. S. Pereira, Nikhil T. Awatade, Cláudia A. Loureiro, Paulo Matos, Margarida D. Amaral, Peter Jordan |
| Abstract |
Cellular models are important tools in various research areas related to colorectal biology and associated diseases. Herein, we review the most widely used cell lines and the different techniques to grow them, either as cell monolayer, polarized two-dimensional epithelia on membrane filters, or as three-dimensional spheres in scaffold-free or matrix-supported culture conditions. Moreover, recent developments, such as gut-on-chip devices or the ex vivo growth of biopsy-derived organoids, are also discussed. We provide an overview on the potential applications but also on the limitations for each of these techniques, while evaluating their contribution to provide more reliable cellular models for research, diagnostic testing, or pharmacological validation related to colon physiology and pathophysiology. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 140 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 138 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 34 | 24% |
| Researcher | 26 | 19% |
| Student > Master | 20 | 14% |
| Student > Bachelor | 12 | 9% |
| Student > Doctoral Student | 8 | 6% |
| Other | 21 | 15% |
| Unknown | 19 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 36 | 26% |
| Agricultural and Biological Sciences | 20 | 14% |
| Medicine and Dentistry | 18 | 13% |
| Engineering | 13 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
| Other | 20 | 14% |
| Unknown | 27 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 May 2016.
All research outputs
#21,141,111
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#3,769
of 4,151 outputs
Outputs of similar age
#255,522
of 300,672 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#79
of 89 outputs
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So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 89 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.