| Title |
Clinical significance of metabolic tumor volume by PET/CT in stages II and III of diffuse large B cell lymphoma without extranodal site involvement
|
|---|---|
| Published in |
Annals of Hematology, November 2011
|
| DOI | 10.1007/s00277-011-1357-2 |
| Pubmed ID | |
| Authors |
Moo-Kon Song, Joo-Seop Chung, Ho-Jin Shin, Sang-Min Lee, Su-Ee Lee, Ho-Sup Lee, Gyeong-Won Lee, Seong-Jang Kim, Seok-Mo Lee, Dong-Seop Chung |
| Abstract |
The objective of this study was to investigate whether metabolic tumor volume (MTV) by positron emission tomography (PET) can be a potential prognostic tool when compared with Ann Arbor stage, in stages II and III nodal diffuse large B cell lymphoma (DLBCL). We evaluated 169 patients with nodal stages II and III DLBCL who underwent measurements with PET prior to rituximab combined with cyclophosphamide, adriamycin, vincristine, and prednisone (R-CHOP). Cutoff point of MTV was measured using the receiver operating characteristic (ROC) curve. During a median period of 36 months, stage II was 59.2% and III was 40.8%. Using the ROC curve, the MTV of 220 cm(3) was the cutoff value. The low MTV group (<220 cm(3)) had longer progression-free survival (PFS) and overall survival (OS), compared with the high MTV group (≥220 cm(3)) (p < 0.001, p < 0.001). Stage II patients had longer survival than those in stage III (PFS, p = 0.011; OS, p = 0.001). The high MTV group had lower PFS and OS patterns, regardless of stage, compared with the low MTV group (p < 0.001, p < 0.001). Multivariate analysis revealed an association of the high MTV group with lower PFS and OS (PFS, hazard ratio (HR) = 5.300, p < 0.001; OS, HR = 7.009, p < 0.001), but not stage III (PFS, p = 0.187; OS, p = 0.054). Assessment of MTV by PET had more potential predictive power than Ann Arbor stage in the patients that received R-CHOP. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 68 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 21% |
| Student > Postgraduate | 9 | 13% |
| Student > Ph. D. Student | 8 | 12% |
| Student > Doctoral Student | 7 | 10% |
| Other | 7 | 10% |
| Other | 11 | 16% |
| Unknown | 12 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 39 | 57% |
| Biochemistry, Genetics and Molecular Biology | 2 | 3% |
| Chemistry | 2 | 3% |
| Agricultural and Biological Sciences | 2 | 3% |
| Computer Science | 2 | 3% |
| Other | 7 | 10% |
| Unknown | 14 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 October 2022.
All research outputs
#4,654,846
of 23,006,268 outputs
Outputs from Annals of Hematology
#216
of 2,200 outputs
Outputs of similar age
#27,440
of 142,921 outputs
Outputs of similar age from Annals of Hematology
#3
of 12 outputs
Altmetric has tracked 23,006,268 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,200 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done well, scoring higher than 89% of its peers.
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We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.