| Title |
Multi-elemental bio-imaging of rat tissue from a study investigating the bioavailability of bismuth from shotgun pellets
|
|---|---|
| Published in |
Analytical & Bioanalytical Chemistry, May 2012
|
| DOI | 10.1007/s00216-012-6101-9 |
| Pubmed ID | |
| Authors |
Dagmar S. Urgast, Dag G. Ellingsen, Balázs Berlinger, Einar Eilertsen, Grete Friisk, Vidar Skaug, Yngvar Thomassen, John H. Beattie, In-Sook Kwun, Jörg Feldmann |
| Abstract |
In recent years, bismuth has been promoted as a "green element" and is used as a substitute for the toxic lead in ammunition and other applications. However, the bioavailability and toxicity of bismuth is still not very well described. Following a hunting accident with bismuth-containing shots, a bioavailability study of bismuth from metal pellets inoculated into rat limb muscles was carried out. Bismuth could be found in urine and blood of the animals. Bio-imaging using laser ablation ICP-MS of thin sections of the tissue around the metal implant was carried out to find out more about the distribution of the metal diffusing into the tissue. Two laser ablation systems with different ablation cell designs were compared regarding their analytical performance. Low concentrations of bismuth showing a non-symmetrical pattern were detected in the tissue surrounding the metal implant. This was partly an artefact from cutting the thin sections but also bio-mobilisation of the metals of the implant could be seen. An accumulation of zinc around the implant was interpreted as a marker of inflammation. Challenges regarding sample preparation for laser ablation and bio-imaging of samples of diverse composition became apparent during the analysis. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 29 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 38% |
| Student > Master | 7 | 24% |
| Researcher | 3 | 10% |
| Student > Bachelor | 2 | 7% |
| Student > Postgraduate | 2 | 7% |
| Other | 3 | 10% |
| Unknown | 1 | 3% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 16 | 55% |
| Medicine and Dentistry | 3 | 10% |
| Nursing and Health Professions | 2 | 7% |
| Chemical Engineering | 1 | 3% |
| Agricultural and Biological Sciences | 1 | 3% |
| Other | 4 | 14% |
| Unknown | 2 | 7% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 May 2012.
All research outputs
#20,656,820
of 25,374,647 outputs
Outputs from Analytical & Bioanalytical Chemistry
#6,601
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Outputs of similar age
#139,439
of 178,354 outputs
Outputs of similar age from Analytical & Bioanalytical Chemistry
#62
of 87 outputs
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