| Title |
Regional reduction in gray and white matter volume in brains of cirrhotic patients: voxel-based analysis of MRI
|
|---|---|
| Published in |
Metabolic Brain Disease, May 2012
|
| DOI | 10.1007/s11011-012-9314-x |
| Pubmed ID | |
| Authors |
Motoh Iwasa, Rumi Mifuji-Moroka, Makoto Kuroda, Hideo Moroka, Naoki Fujita, Yoshinao Kobayashi, Yukihiko Adachi, Esteban C. Gabazza, Hiroshi Matsuda, Yoshiyuki Takei |
| Abstract |
Chronic hepatic encephalopathy is a characteristically reversible neuropsychiatric disorder that occurs mainly in patients with liver cirrhosis. The brain regions critically involved in the pathophysiology of cirrhosis are not clear. Magnetic resonance imaging (MRI) with voxel-based morphometry (VBM) is a valuable tool for evaluating structural brain changes in many neurodegenerative diseases. We performed an MRI scan on 18 patients with liver cirrhosis and 16 age-matched healthy controls. We evaluated brain regional structural changes, regional differences and the relationship of these changes with the blood levels of ammonia and the results of neuropsychological tests in patients with cirrhosis. The VBM showed reduction in the volume of gray matter in the cerebellum and occipital lobe and in the volume of white matter in the cingulate, parietal, temporal, occipital lobe and precentral area in cirrhotic patients compared with controls. There were significant correlations between the volume of these regions with the plasma levels of ammonia and the results of neuropsychological tests. Voxel-based analysis of MRI revealed evidence for structural abnormalities of brain in patients with cirrhosis. Abnormal function in the above regions may account for the ammonia-mediated changes and neuropsychological deficits in hepatic encephalopathy. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 6% |
| Canada | 1 | 3% |
| Unknown | 29 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 19% |
| Student > Master | 6 | 19% |
| Student > Bachelor | 4 | 13% |
| Other | 3 | 9% |
| Researcher | 3 | 9% |
| Other | 8 | 25% |
| Unknown | 2 | 6% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 31% |
| Neuroscience | 8 | 25% |
| Psychology | 5 | 16% |
| Sports and Recreations | 2 | 6% |
| Agricultural and Biological Sciences | 1 | 3% |
| Other | 3 | 9% |
| Unknown | 3 | 9% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2012.
All research outputs
#18,308,895
of 22,668,244 outputs
Outputs from Metabolic Brain Disease
#708
of 1,050 outputs
Outputs of similar age
#126,108
of 163,862 outputs
Outputs of similar age from Metabolic Brain Disease
#11
of 15 outputs
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