| Title |
Human induced pluripotent stem cells—from mechanisms to clinical applications
|
|---|---|
| Published in |
Journal of Molecular Medicine, May 2012
|
| DOI | 10.1007/s00109-012-0913-0 |
| Pubmed ID | |
| Authors |
Katharina Drews, Justyna Jozefczuk, Alessandro Prigione, James Adjaye |
| Abstract |
Human pluripotent stem cells hold great promise for basic research and regenerative medicine due to their inherent property to propagate infinitely, while maintaining the potential to differentiate into any given cell type of the human body. Since the first derivation in 1998, pluripotent human embryonic stem cells (ESCs) have been studied intensively, and although these cells provoke ethical and immune rejection concerns, translation of human ESC research into the clinics has been initiated. The generation of embryonic stem cell-like human induced pluripotent stem cells (iPSCs) from somatic cells by virus-mediated overexpression of distinct sets of reprogramming factors (OCT4, SOX2, KLF4, and c-MYC, or OCT4, SOX2, NANOG, and LIN28) in 2007 has opened up further opportunities in the field. While circumventing the major disputes associated with human ESCs, iPSCs offer the same advantages and, in addition, new perspectives for personalized medicine. This review summarizes technical advances toward the generation of potentially clinically relevant human iPSCs. We also highlight key molecular events underlying the process of cellular reprogramming and discuss inherent features of iPSCs, including genome instability and epigenetic memory. Furthermore, we will give an overview of particular envisaged human iPSC applications and point out which improvements are yet to come and what has been achieved so far. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Netherlands | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Unknown | 118 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 24% |
| Researcher | 19 | 16% |
| Student > Master | 19 | 16% |
| Student > Bachelor | 19 | 16% |
| Student > Postgraduate | 8 | 7% |
| Other | 16 | 13% |
| Unknown | 11 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 56 | 46% |
| Medicine and Dentistry | 17 | 14% |
| Biochemistry, Genetics and Molecular Biology | 16 | 13% |
| Neuroscience | 5 | 4% |
| Engineering | 4 | 3% |
| Other | 13 | 11% |
| Unknown | 10 | 8% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2012.
All research outputs
#18,308,895
of 22,668,244 outputs
Outputs from Journal of Molecular Medicine
#1,248
of 1,547 outputs
Outputs of similar age
#126,938
of 165,091 outputs
Outputs of similar age from Journal of Molecular Medicine
#14
of 18 outputs
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