Title |
A mechanistic basis for potent, glycoprotein B-directed gammaherpesvirus neutralization
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Published in |
Journal of General Virology, May 2011
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DOI | 10.1099/vir.0.032177-0 |
Pubmed ID | |
Authors |
Daniel L. Glauser, Anne-Sophie Kratz, Laurent Gillet, Philip G. Stevenson |
Abstract |
Glycoprotein B (gB) is a conserved, essential component of gammaherpes virions and so potentially vulnerable to neutralization. However, few good gB-specific neutralizing antibodies have been identified. Here, we show that murid herpesvirus 4 is strongly neutralized by mAbs that recognize an epitope close to one of the gB fusion loops. Antibody binding did not stop gB interacting with its cellular ligands or initiating its fusion-associated conformation change, but did stop gB resolving stably to its post-fusion form, and so blocked membrane fusion to leave virions stranded in late endosomes. The conservation of gB makes this mechanism a possible general route to gammaherpesvirus neutralization. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 7% |
Unknown | 14 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 6 | 40% |
Researcher | 4 | 27% |
Professor | 1 | 7% |
Student > Postgraduate | 1 | 7% |
Unknown | 3 | 20% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 7 | 47% |
Immunology and Microbiology | 2 | 13% |
Biochemistry, Genetics and Molecular Biology | 1 | 7% |
Veterinary Science and Veterinary Medicine | 1 | 7% |
Medicine and Dentistry | 1 | 7% |
Other | 0 | 0% |
Unknown | 3 | 20% |