| Title |
Learning to forget: manipulating extinction and reconsolidation processes to treat addiction
|
|---|---|
| Published in |
Psychopharmacology, May 2012
|
| DOI | 10.1007/s00213-012-2750-9 |
| Pubmed ID | |
| Authors |
Mary M. Torregrossa, Jane R. Taylor |
| Abstract |
Finding effective long-lasting treatments for drug addiction has been an elusive goal. Consequently, researchers are beginning to investigate novel treatment strategies including manipulations of drug-associated memories. When environmental stimuli (cues) become associated with drug use, they become powerful motivators of continued drug use and relapse after abstinence. Reducing the strength of these cue-drug memories could decrease the number of factors that induce craving and relapse to aid in the treatment of addiction. Enhancing the consolidation of extinction learning and/or disrupting cue-drug memory reconsolidation are two strategies that have been proposed to reduce the strength of cues in motivating drug-seeking and drug-taking behavior. Here, we review the latest basic and clinical research elucidating the mechanisms underlying consolidation of extinction and reconsolidation of cue-drug memories in the hopes of developing pharmacological tools that exploit these signaling systems to treat addiction. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Canada | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 251 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | <1% |
| Switzerland | 1 | <1% |
| Italy | 1 | <1% |
| Australia | 1 | <1% |
| Brazil | 1 | <1% |
| United Kingdom | 1 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 243 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 48 | 19% |
| Student > Bachelor | 43 | 17% |
| Researcher | 35 | 14% |
| Student > Master | 33 | 13% |
| Student > Doctoral Student | 14 | 6% |
| Other | 43 | 17% |
| Unknown | 35 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 60 | 24% |
| Neuroscience | 47 | 19% |
| Agricultural and Biological Sciences | 38 | 15% |
| Medicine and Dentistry | 21 | 8% |
| Social Sciences | 6 | 2% |
| Other | 33 | 13% |
| Unknown | 46 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 41. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 July 2020.
All research outputs
#846,725
of 22,668,244 outputs
Outputs from Psychopharmacology
#212
of 5,330 outputs
Outputs of similar age
#4,727
of 164,803 outputs
Outputs of similar age from Psychopharmacology
#5
of 41 outputs
Altmetric has tracked 22,668,244 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,330 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 164,803 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.