Title |
The KRAS-Variant Is Associated with Risk of Developing Double Primary Breast and Ovarian Cancer
|
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Published in |
PLOS ONE, May 2012
|
DOI | 10.1371/journal.pone.0037891 |
Pubmed ID | |
Authors |
Robert Pilarski, Divya A. Patel, Jeffrey Weitzel, Terri McVeigh, Jemima J. Dorairaj, Helen M. Heneghan, Nicola Miller, Joanne B. Weidhaas, Michael J. Kerin, Megan McKenna, Xifeng Wu, Michelle Hildebrandt, Daniel Zelterman, Sharon Sand, Lee P. Shulman |
Abstract |
A germline microRNA binding site-disrupting variant, the KRAS-variant (rs61764370), is associated with an increased risk of developing several cancers. Because this variant is most strongly associated with ovarian cancer risk in patients from hereditary breast and ovarian families (HBOC), and with the risk of premenopausal triple negative breast cancer, we evaluated the association of the KRAS-variant with women with personal histories of both breast and ovarian cancer, referred to as double primary patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 3% |
China | 1 | 3% |
Unknown | 35 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 16% |
Researcher | 5 | 14% |
Student > Master | 4 | 11% |
Other | 3 | 8% |
Student > Postgraduate | 3 | 8% |
Other | 9 | 24% |
Unknown | 7 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 24% |
Biochemistry, Genetics and Molecular Biology | 7 | 19% |
Agricultural and Biological Sciences | 7 | 19% |
Mathematics | 1 | 3% |
Unspecified | 1 | 3% |
Other | 4 | 11% |
Unknown | 8 | 22% |