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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Mincle polarizes human monocyte and neutrophil responses to Candida albicans
|
|---|---|
| Published in |
Immunology & Cell Biology, May 2012
|
| DOI | 10.1038/icb.2012.24 |
| Pubmed ID | |
| Authors |
Dipti Vijayan, Kristen J Radford, Anthony G Beckhouse, Robert B Ashman, Christine A Wells |
| Abstract |
The distribution and function of the C-type lectin Mincle has not previously been investigated in human cells, although mouse models have demonstrated a non-redundant role for Mincle in the host response to fungal infections. This study identified an unusual pattern of reciprocal expression of Mincle on peripheral blood monocytes or neutrophils isolated from the same donor. Expression on monocytes was inversely correlated with phagocytosis and yeast killing, but was necessary for the induction of inflammatory cytokines in response to ex vivo Candida challenge. In contrast, Mincle expression on neutrophils was associated with phagocytic and candidacidal potential of those cells. Candida challenge upregulated Mincle expression but only in Mincle+ cells. These data highlight species-specific differences between the regulation of Mincle expression in mouse and man. Reciprocal expression of Mincle modified the candidacidal potential of monocytes or neutrophils, suggesting it may also polarize the type of host response to fungal infection. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 2% |
| Australia | 1 | 2% |
| Canada | 1 | 2% |
| Unknown | 57 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 22% |
| Student > Bachelor | 8 | 13% |
| Student > Ph. D. Student | 8 | 13% |
| Student > Master | 7 | 12% |
| Student > Doctoral Student | 4 | 7% |
| Other | 10 | 17% |
| Unknown | 10 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 19 | 32% |
| Immunology and Microbiology | 11 | 18% |
| Medicine and Dentistry | 8 | 13% |
| Biochemistry, Genetics and Molecular Biology | 6 | 10% |
| Chemistry | 4 | 7% |
| Other | 2 | 3% |
| Unknown | 10 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2012.
All research outputs
#20,656,161
of 25,373,627 outputs
Outputs from Immunology & Cell Biology
#1,722
of 1,848 outputs
Outputs of similar age
#139,678
of 178,782 outputs
Outputs of similar age from Immunology & Cell Biology
#5
of 7 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,848 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one is in the 2nd percentile – i.e., 2% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 178,782 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.