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Cyclization of 4‑Phenoxy-2-coumarins and 2‑Pyrones via a Double C–H Activation

Overview of attention for article published in Organic Letters, May 2016
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  • Good Attention Score compared to outputs of the same age (67th percentile)
  • Good Attention Score compared to outputs of the same age and source (76th percentile)

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Title
Cyclization of 4‑Phenoxy-2-coumarins and 2‑Pyrones via a Double C–H Activation
Published in
Organic Letters, May 2016
DOI 10.1021/acs.orglett.6b00751
Pubmed ID
Authors

Katrina Mackey, Leticia M. Pardo, Aisling M. Prendergast, Marie-T. Nolan, Lorraine M. Bateman, Gerard P. McGlacken

Abstract

Aryl-heteroaryl coupling via double C-H activation is a powerful transformation that avoids the installation of activating groups. A double C-H activation of privileged biological scaffolds, 2-coumarins and 2-pyrones, is reported. Despite the rich chemistry of these molecular frameworks, the yields are very good. Excellent regioselectivity was achieved on the pyrones. This methodology was applied to the synthesis of flemichapparin C in three steps. Isotope effect experiments were carried out, and a mechanism is proposed.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 40 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 15%
Student > Bachelor 2 5%
Researcher 2 5%
Professor > Associate Professor 2 5%
Student > Master 1 3%
Other 3 8%
Unknown 24 60%
Readers by discipline Count As %
Chemistry 14 35%
Unknown 26 65%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 May 2016.
All research outputs
#6,812,377
of 22,873,031 outputs
Outputs from Organic Letters
#4,913
of 14,101 outputs
Outputs of similar age
#106,948
of 334,143 outputs
Outputs of similar age from Organic Letters
#37
of 155 outputs
Altmetric has tracked 22,873,031 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 14,101 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 334,143 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 155 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.