| Title |
HIV Incidence in Young Girls in KwaZulu-Natal, South Africa-Public Health Imperative for Their Inclusion in HIV Biomedical Intervention Trials
|
|---|---|
| Published in |
AIDS and Behavior, May 2012
|
| DOI | 10.1007/s10461-012-0209-y |
| Pubmed ID | |
| Authors |
Quarraisha Abdool Karim, Ayesha B. M. Kharsany, Janet A. Frohlich, Lise Werner, Mukelisiwe Mlotshwa, Bernadette T. Madlala, Salim S. Abdool Karim |
| Abstract |
Young women are particularly vulnerable for acquiring HIV yet they are often excluded from clinical trials testing new biomedical intervention. We assessed the HIV incidence and feasibility of enrolling a cohort of young women for potential participation in future clinical trials. Between March 2004 and May 2007, 594 HIV uninfected 14-30 year old women were enrolled into a longitudinal HIV risk reduction study in KwaZulu-Natal, South Africa. The overall HIV prevalence at screening in young girls below the age of 18 years was 27.6 % compared to 52.0 % in the women above 18 years, p < 0.001. HIV incidence was 4.7 [95 % Confidence interval (CI) 1.5-10.9) and 6.9 (95 % CI 4.8-9.6)/100 women years (wy), p = 0.42 and pregnancy rates were 23.7 (95 % CI 14.9-35.9) and 16.4 (95 % CI 12.9-20.6)/100 wy, p = 0.29, in the women below and above 18 years respectively. Retention was similar in both groups (71.0 vs. 71.5 %, p = 0.90). This study demonstrates that the inclusion of young girls between the ages of 14 and 17 years in longitudinal studies is feasible and their inclusion in clinical trials would maintain scientific integrity and power of the study. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| South Africa | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 132 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Australia | 1 | <1% |
| South Africa | 1 | <1% |
| Unknown | 128 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 29 | 22% |
| Student > Ph. D. Student | 26 | 20% |
| Researcher | 18 | 14% |
| Student > Doctoral Student | 13 | 10% |
| Other | 9 | 7% |
| Other | 26 | 20% |
| Unknown | 11 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 23 | 17% |
| Social Sciences | 22 | 17% |
| Nursing and Health Professions | 14 | 11% |
| Psychology | 12 | 9% |
| Agricultural and Biological Sciences | 9 | 7% |
| Other | 29 | 22% |
| Unknown | 23 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 March 2017.
All research outputs
#6,773,523
of 23,849,058 outputs
Outputs from AIDS and Behavior
#1,089
of 3,566 outputs
Outputs of similar age
#46,024
of 166,276 outputs
Outputs of similar age from AIDS and Behavior
#18
of 55 outputs
Altmetric has tracked 23,849,058 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 3,566 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 166,276 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.