| Title |
The role of epigenetic regulation in stem cell and cancer biology
|
|---|---|
| Published in |
Journal of Molecular Medicine, June 2012
|
| DOI | 10.1007/s00109-012-0917-9 |
| Pubmed ID | |
| Authors |
Lilian E. van Vlerken, Elaine M. Hurt, Robert E. Hollingsworth |
| Abstract |
Normal development and homeostasis requires a carefully coordinated gene expression program. Appropriate transcriptional regulation is maintained, in part, through epigenetic modifications of both DNA and histones. It is now apparent that the epigenetic landscape is complex and carefully controlled to both silence and activate gene transcription and that these states remain exquisitely poised for reversal. The deregulation of epigenetics in cancer is common and results in both the activation of oncogenes and the silencing of tumor suppressors. A tremendous amount of research corroborates the existence in many tumor types of a cancer stem cell that is both the origin and cell type responsible for resistance of tumors to current therapies. As our understanding of cancer stem cell biology continues, it is apparent that these cells are also under the influence of epigenetic regulation. We will discuss the cancer stem cell hypothesis and the role of epigenetics in both normal and cancer stem cell biology. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 2 | 3% |
| Denmark | 1 | 2% |
| Unknown | 55 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 19% |
| Researcher | 11 | 19% |
| Student > Bachelor | 6 | 10% |
| Student > Master | 6 | 10% |
| Professor > Associate Professor | 5 | 9% |
| Other | 9 | 16% |
| Unknown | 10 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 20 | 34% |
| Biochemistry, Genetics and Molecular Biology | 13 | 22% |
| Medicine and Dentistry | 10 | 17% |
| Chemistry | 3 | 5% |
| Immunology and Microbiology | 1 | 2% |
| Other | 2 | 3% |
| Unknown | 9 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2024.
All research outputs
#7,892,319
of 25,260,058 outputs
Outputs from Journal of Molecular Medicine
#511
of 1,638 outputs
Outputs of similar age
#52,360
of 171,536 outputs
Outputs of similar age from Journal of Molecular Medicine
#3
of 18 outputs
Altmetric has tracked 25,260,058 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 1,638 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 171,536 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.