| Title |
SERS-based plasmonic nanobiosensing in single living cells
|
|---|---|
| Published in |
Analytical & Bioanalytical Chemistry, December 2008
|
| DOI | 10.1007/s00216-008-2521-y |
| Pubmed ID | |
| Authors |
Jonathan P. Scaffidi, Molly K. Gregas, Victoria Seewaldt, Tuan Vo-Dinh |
| Abstract |
In this paper, we describe the development and application of a pH-sensitive plasmonics-active fiber-optic nanoprobe suitable for intracellular bioanalysis in single living human cells using surface-enhanced Raman scattering (SERS) detection. The effectiveness and usefulness of SERS-based fiber-optic nanoprobes are illustrated by measurements of intracellular pH in HMEC-15/hTERT immortalized "normal" human mammary epithelial cells and PC-3 human prostate cancer cells. The results indicate that fiber-optic nanoprobe insertion and interrogation provide a sensitive and selective means to monitor cellular microenvironments at the single cell level. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Turkey | 1 | 1% |
| France | 1 | 1% |
| United Kingdom | 1 | 1% |
| Iran, Islamic Republic of | 1 | 1% |
| Mexico | 1 | 1% |
| China | 1 | 1% |
| Unknown | 88 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 35% |
| Researcher | 20 | 21% |
| Student > Bachelor | 9 | 10% |
| Student > Master | 8 | 9% |
| Student > Doctoral Student | 6 | 6% |
| Other | 12 | 13% |
| Unknown | 6 | 6% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 23 | 24% |
| Chemistry | 21 | 22% |
| Physics and Astronomy | 14 | 15% |
| Materials Science | 11 | 12% |
| Agricultural and Biological Sciences | 5 | 5% |
| Other | 7 | 7% |
| Unknown | 13 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2012.
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#20,838,163
of 25,604,262 outputs
Outputs from Analytical & Bioanalytical Chemistry
#6,654
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Outputs of similar age
#168,093
of 179,621 outputs
Outputs of similar age from Analytical & Bioanalytical Chemistry
#39
of 40 outputs
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