Title |
Artemisinin resistance: current status and scenarios for containment
|
---|---|
Published in |
Nature Reviews Microbiology, March 2010
|
DOI | 10.1038/nrmicro2331 |
Pubmed ID | |
Authors |
Arjen M. Dondorp, Shunmay Yeung, Lisa White, Chea Nguon, Nicholas P.J. Day, Duong Socheat, Lorenz von Seidlein |
Abstract |
Artemisinin combination therapies are the first-line treatments for uncomplicated Plasmodium falciparum malaria in most malaria-endemic countries. Recently, partial artemisinin-resistant P. falciparum malaria has emerged on the Cambodia-Thailand border. Exposure of the parasite population to artemisinin monotherapies in subtherapeutic doses for over 30 years, and the availability of substandard artemisinins, have probably been the main driving force in the selection of the resistant phenotype in the region. A multifaceted containment programme has recently been launched, including early diagnosis and appropriate treatment, decreasing drug pressure, optimising vector control, targeting the mobile population, strengthening management and surveillance systems, and operational research. Mathematical modelling can be a useful tool to evaluate possible strategies for containment. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Uganda | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 11 | 2% |
United States | 3 | <1% |
Tanzania, United Republic of | 2 | <1% |
Belgium | 2 | <1% |
Thailand | 2 | <1% |
Ireland | 2 | <1% |
Mexico | 2 | <1% |
Brazil | 2 | <1% |
Vietnam | 1 | <1% |
Other | 10 | 2% |
Unknown | 621 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 133 | 20% |
Student > Master | 119 | 18% |
Researcher | 102 | 16% |
Student > Bachelor | 75 | 11% |
Student > Postgraduate | 41 | 6% |
Other | 101 | 15% |
Unknown | 87 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 180 | 27% |
Medicine and Dentistry | 100 | 15% |
Chemistry | 83 | 13% |
Biochemistry, Genetics and Molecular Biology | 77 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 34 | 5% |
Other | 76 | 12% |
Unknown | 108 | 16% |