| Title |
Heat Shock Protein 70: Roles in Multiple Sclerosis
|
|---|---|
| Published in |
Molecular Medicine, June 2012
|
| DOI | 10.2119/molmed.2012.00119 |
| Pubmed ID | |
| Authors |
María José Mansilla, Xavier Montalban, Carmen Espejo |
| Abstract |
Heat shock proteins (HSP) have long been considered intracellular chaperones that possess housekeeping and cytoprotective functions. Consequently, HSP overexpression was proposed as a potential therapy for neurodegenerative diseases characterized by the accumulation or aggregation of abnormal proteins. Recently, the discovery that cells release HSP with the capacity to trigger proinflammatory as well as immunoregulatory responses has focused attention on investigating the role of HSP in chronic inflammatory autoimmune diseases such as multiple sclerosis (MS). To date, the most relevant HSP is the inducible Hsp70, which exhibits both cytoprotectant and immunoregulatory functions. Several studies have presented contradictory evidence concerning the involvement of Hsp70 in MS or experimental autoimmune encephalomyelitis (EAE), the MS animal model. In this review, we dissect the functions of Hsp70 and discuss the controversial data concerning the role of Hsp70 in MS and EAE. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | 1% |
| Spain | 1 | 1% |
| Italy | 1 | 1% |
| Unknown | 69 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 19 | 26% |
| Student > Ph. D. Student | 18 | 25% |
| Researcher | 12 | 17% |
| Other | 4 | 6% |
| Student > Bachelor | 3 | 4% |
| Other | 6 | 8% |
| Unknown | 10 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 25% |
| Neuroscience | 13 | 18% |
| Medicine and Dentistry | 11 | 15% |
| Biochemistry, Genetics and Molecular Biology | 7 | 10% |
| Immunology and Microbiology | 3 | 4% |
| Other | 9 | 13% |
| Unknown | 11 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 June 2012.
All research outputs
#20,159,700
of 22,668,244 outputs
Outputs from Molecular Medicine
#990
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Outputs of similar age
#149,296
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Outputs of similar age from Molecular Medicine
#11
of 11 outputs
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