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Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study

Overview of attention for article published in British Journal of Cancer, May 2012
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Title
Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study
Published in
British Journal of Cancer, May 2012
DOI 10.1038/bjc.2012.160
Pubmed ID
Authors

A Jakubowska, D Rozkrut, A Antoniou, U Hamann, R J Scott, L McGuffog, S Healy, O M Sinilnikova, G Rennert, F Lejbkowicz, A Flugelman, I L Andrulis, G Glendon, H Ozcelik, OCGN, M Thomassen, M Paligo, P Aretini, SWE-BRCA, J Kantala, B Aroer, A von Wachenfeldt, A Liljegren, N Loman, K Herbst, U Kristoffersson, R Rosenquist, P Karlsson, M Stenmark-Askmalm, B Melin, K L Nathanson, S M Domchek, T Byrski, T Huzarski, J Gronwald, J Menkiszak, C Cybulski, P Serrano, A Osorio, T R Cajal, M Tsitlaidou, J Benítez, M Gilbert, HEBON, M Rookus, C M Aalfs, I Kluijt, J L Boessenkool-Pape, H E J Meijers-Heijboer, J C Oosterwijk, C J van Asperen, M J Blok, M R Nelen, A M W van den Ouweland, C Seynaeve, R B van der Luijt, P Devilee, EMBRACE, D F Easton, S Peock, D Frost, R Platte, S D Ellis, E Fineberg, D G Evans, F Lalloo, R Eeles, C Jacobs, J Adlard, R Davidson, D Eccles, T Cole, J Cook, A Godwin, B Bove, GEMO Study Collaborators, D Stoppa-Lyonnet, V Caux-Moncoutier, M Belotti, C Tirapo, S Mazoyer, L Barjhoux, N Boutry-Kryza, P Pujol, I Coupier, J-P Peyrat, P Vennin, D Muller, J-P Fricker, L Venat-Bouvet, O Th Johannsson, C Isaacs, R Schmutzler, B Wappenschmidt, A Meindl, N Arnold, R Varon-Mateeva, D Niederacher, C Sutter, H Deissler, S Preisler-Adams, J Simard, P Soucy, F Durocher, G Chenevix-Trench, J Beesley, X Chen, KConFab, T Rebbeck, F Couch, X Wang, N Lindor, Z Fredericksen, V S Pankratz, P Peterlongo, B Bonanni, S Fortuzzi, B Peissel, C Szabo, P L Mai, J T Loud, J Lubinski, on behalf of CIMBA, the Consortium of Investigators of Modifiers of BRCA1/2-Related Cancer

Abstract

The variable penetrance of breast cancer in BRCA1/2 mutation carriers suggests that other genetic or environmental factors modify breast cancer risk. Two genes of special interest are prohibitin (PHB) and methylene-tetrahydrofolate reductase (MTHFR), both of which are important either directly or indirectly in maintaining genomic integrity.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Russia 1 2%
Unknown 43 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 18%
Professor > Associate Professor 6 14%
Researcher 6 14%
Other 4 9%
Professor 4 9%
Other 8 18%
Unknown 8 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 30%
Medicine and Dentistry 11 25%
Biochemistry, Genetics and Molecular Biology 7 16%
Energy 1 2%
Economics, Econometrics and Finance 1 2%
Other 2 5%
Unknown 9 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 June 2012.
All research outputs
#18,308,895
of 22,668,244 outputs
Outputs from British Journal of Cancer
#9,640
of 10,349 outputs
Outputs of similar age
#126,152
of 163,698 outputs
Outputs of similar age from British Journal of Cancer
#77
of 92 outputs
Altmetric has tracked 22,668,244 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,349 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.6. This one is in the 3rd percentile – i.e., 3% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 163,698 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 92 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.