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A Genome-Wide Study on the Perception of the Odorants Androstenone and Galaxolide

Overview of attention for article published in Chemical Senses, February 2012
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Title
A Genome-Wide Study on the Perception of the Odorants Androstenone and Galaxolide
Published in
Chemical Senses, February 2012
DOI 10.1093/chemse/bjs008
Pubmed ID
Authors

Antti Knaapila, Gu Zhu, Sarah E. Medland, Charles J. Wysocki, Grant W. Montgomery, Nicholas G. Martin, Margaret J. Wright, Danielle R. Reed

Abstract

Twin pairs and their siblings rated the intensity of the odorants amyl acetate, androstenone, eugenol, Galaxolide, mercaptans, and rose (N = 1573). Heritability was established for ratings of androstenone (h (2) = 0.30) and Galaxolide (h(2) = 0.34) but not for the other odorants. Genome-wide association analysis using 2.3 million single nucleotide polymorphisms indicated that the most significant association was between androstenone and a region without known olfactory receptor genes (rs10966900, P = 1.2 × 10(-7)). A previously reported association between the olfactory receptor OR7D4 and the androstenone was not detected until we specifically typed this gene (P = 1.1 × 10(-4)). We also tested these 2 associations in a second independent sample of subjects and replicated the results either fully (OR7D4, P = 0.00002) or partially (rs10966900, P = 0.010; N = 266). These findings suggest that 1) the perceived intensity of some but not all odorants is a heritable trait, 2) use of a current genome-wide marker panel did not detect a known olfactory genotype-phenotype association, and 3) person-to-person differences in androstenone perception are influenced by OR7D4 genotype and perhaps by variants of other genes.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Netherlands 1 2%
Sweden 1 2%
Denmark 1 2%
Unknown 39 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 26%
Student > Ph. D. Student 7 16%
Student > Master 5 12%
Student > Bachelor 4 9%
Professor 3 7%
Other 5 12%
Unknown 8 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 35%
Neuroscience 5 12%
Biochemistry, Genetics and Molecular Biology 4 9%
Psychology 4 9%
Medicine and Dentistry 2 5%
Other 3 7%
Unknown 10 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 April 2020.
All research outputs
#20,655,488
of 25,371,288 outputs
Outputs from Chemical Senses
#1,025
of 1,173 outputs
Outputs of similar age
#132,767
of 169,009 outputs
Outputs of similar age from Chemical Senses
#10
of 11 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
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We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.