| Title |
In vivo evidence of the immunomodulatory activity of orally administered Aloe vera gel
|
|---|---|
| Published in |
Archives of Pharmacal Research, March 2010
|
| DOI | 10.1007/s12272-010-0315-1 |
| Pubmed ID | |
| Authors |
Sun-A. Im, Young-Ran Lee, Young-Hee Lee, Myung-Koo Lee, Young In Park, Sungwon Lee, Kyungjae Kim, Chong-Kil Lee |
| Abstract |
The gels of Aloe species contain immunomodulatory components such as aloctin A and acemannan. Most studies on these gels were performed in in vitro cell culture systems. Although several studies examined their immunomodulatory activity in vivo, the route of administration was intraperitoneal or intramuscular. Here, we evaluated the in vivo immunomodulatory activity of processed Aloe vera gel (PAG) in mice. Oral administration of PAG significantly reduced the growth of C. albicans in the spleen and kidney following intravenous injection of C. albicans in normal mice. PAG administration also reduced the growth of C. albicans in streptozotocin-induced diabetic mice. PAG administration did not increase ovalbumin (OVA)-specific cytotoxic T lymphocyte (CTL) generation in normal mice, but did increase it in high-fat-diet induced diabetic mice. These findings provide the first clear evidence for the immunomodulatory activity of orally administered Aloe vera gel. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 77 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 17% |
| Researcher | 10 | 13% |
| Student > Master | 10 | 13% |
| Student > Bachelor | 6 | 8% |
| Student > Postgraduate | 5 | 6% |
| Other | 12 | 16% |
| Unknown | 21 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 14 | 18% |
| Medicine and Dentistry | 10 | 13% |
| Biochemistry, Genetics and Molecular Biology | 9 | 12% |
| Chemistry | 8 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
| Other | 10 | 13% |
| Unknown | 22 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 November 2018.
All research outputs
#2,919,351
of 22,668,244 outputs
Outputs from Archives of Pharmacal Research
#72
of 1,292 outputs
Outputs of similar age
#11,523
of 94,924 outputs
Outputs of similar age from Archives of Pharmacal Research
#1
of 20 outputs
Altmetric has tracked 22,668,244 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,292 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done particularly well, scoring higher than 94% of its peers.
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We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.