| Title |
Prediction of Nonlinear Intestinal Absorption of CYP3A4 and P-Glycoprotein Substrates from their In Vitro Km Values
|
|---|---|
| Published in |
Pharmaceutical Research, September 2011
|
| DOI | 10.1007/s11095-011-0579-2 |
| Pubmed ID | |
| Authors |
Tatsuhiko Tachibana, Motohiro Kato, Yuichi Sugiyama |
| Abstract |
CYP3A4 and P-glycoprotein (P-gp) are present in the human intestine and mediate intestinal first-pass metabolism and the efflux of oral drugs, respectively. We aimed to predict whether intestinal CYP3A4/P-gp is saturated in a therapeutic dose range. |
Mendeley readers
The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 2% |
| Unknown | 51 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 31% |
| Student > Ph. D. Student | 8 | 15% |
| Student > Master | 5 | 10% |
| Student > Bachelor | 4 | 8% |
| Professor > Associate Professor | 3 | 6% |
| Other | 7 | 13% |
| Unknown | 9 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 25% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 23% |
| Agricultural and Biological Sciences | 11 | 21% |
| Biochemistry, Genetics and Molecular Biology | 3 | 6% |
| Chemistry | 2 | 4% |
| Other | 1 | 2% |
| Unknown | 10 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 June 2012.
All research outputs
#20,159,700
of 22,668,244 outputs
Outputs from Pharmaceutical Research
#2,637
of 2,848 outputs
Outputs of similar age
#116,101
of 126,285 outputs
Outputs of similar age from Pharmaceutical Research
#34
of 34 outputs
Altmetric has tracked 22,668,244 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,848 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.