| Title |
Role of helminths in regulating mucosal inflammation
|
|---|---|
| Published in |
Seminars in Immunopathology, June 2005
|
| DOI | 10.1007/s00281-005-0209-3 |
| Pubmed ID | |
| Authors |
Joel V. Weinstock, Robert W. Summers, David E. Elliott |
| Abstract |
The rapid rise in prevalence of ulcerative colitis (UC) and Crohn's disease (CD) in highly developed countries suggests that environmental change engenders risk for inflammatory bowel disease (IBD). Eradication of parasitic worms (helminths) through increased hygiene may be one such change that has led to increased prevalence of these diseases. Helminths alter host mucosal and systemic immunity, inhibiting dysregulated inflammatory responses. Animals exposed to helminths are protected from experimental colitis, encephalitis, and diabetes. Patients with CD or UC improve when exposed to whipworm. Lamina propria (LP) mononuclear cells from helminth-colonized mice make less interleukin (IL)-12 p40 and IFN-gamma, but more IL-4, IL-13, IL-10, TGF-beta, and PGE(2) compared to LP mononuclear cells from naive mice. Systemic immune responses show similar skewing toward Th2 and regulatory cytokine production in worm-colonized animal models and humans. Recent reports suggest that helminths induce regulatory T cell activity. These effects by once ubiquitous organisms may have protected individuals from many of the emerging immune-mediated illnesses like IBD, multiple sclerosis, type I diabetes, and asthma. |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Tanzania, United Republic of | 1 | 1% |
| Australia | 1 | 1% |
| United Kingdom | 1 | 1% |
| Czechia | 1 | 1% |
| Mexico | 1 | 1% |
| Serbia | 1 | 1% |
| Unknown | 68 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 13 | 17% |
| Researcher | 12 | 16% |
| Student > Ph. D. Student | 10 | 13% |
| Student > Bachelor | 8 | 11% |
| Student > Doctoral Student | 5 | 7% |
| Other | 19 | 25% |
| Unknown | 9 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 22 | 29% |
| Medicine and Dentistry | 16 | 21% |
| Immunology and Microbiology | 9 | 12% |
| Biochemistry, Genetics and Molecular Biology | 7 | 9% |
| Nursing and Health Professions | 2 | 3% |
| Other | 9 | 12% |
| Unknown | 11 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 July 2012.
All research outputs
#8,262,981
of 25,374,917 outputs
Outputs from Seminars in Immunopathology
#280
of 717 outputs
Outputs of similar age
#23,486
of 67,432 outputs
Outputs of similar age from Seminars in Immunopathology
#1
of 2 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 717 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 67,432 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them