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Mendeley readers
Attention Score in Context
| Title |
Mutant PrP Suppresses Glutamatergic Neurotransmission in Cerebellar Granule Neurons by Impairing Membrane Delivery of VGCC α2δ-1 Subunit
|
|---|---|
| Published in |
Neuron, April 2012
|
| DOI | 10.1016/j.neuron.2012.02.027 |
| Pubmed ID | |
| Authors |
Assunta Senatore, Simona Colleoni, Claudia Verderio, Elena Restelli, Raffaella Morini, Steven B. Condliffe, Ilaria Bertani, Susanna Mantovani, Mara Canovi, Edoardo Micotti, Gianluigi Forloni, Annette C. Dolphin, Michela Matteoli, Marco Gobbi, Roberto Chiesa |
| Abstract |
How mutant prion protein (PrP) leads to neurological dysfunction in genetic prion diseases is unknown. Tg(PG14) mice synthesize a misfolded mutant PrP which is partially retained in the neuronal endoplasmic reticulum (ER). As these mice age, they develop ataxia and massive degeneration of cerebellar granule neurons (CGNs). Here, we report that motor behavioral deficits in Tg(PG14) mice emerge before neurodegeneration and are associated with defective glutamate exocytosis from granule neurons due to impaired calcium dynamics. We found that mutant PrP interacts with the voltage-gated calcium channel α(2)δ-1 subunit, which promotes the anterograde trafficking of the channel. Owing to ER retention of mutant PrP, α(2)δ-1 accumulates intracellularly, impairing delivery of the channel complex to the cell surface. Thus, mutant PrP disrupts cerebellar glutamatergic neurotransmission by reducing the number of functional channels in CGNs. These results link intracellular PrP retention to synaptic dysfunction, indicating new modalities of neurotoxicity and potential therapeutic strategies. |
Mendeley readers
The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 3% |
| United Kingdom | 1 | 1% |
| Germany | 1 | 1% |
| Unknown | 84 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 25% |
| Researcher | 18 | 20% |
| Professor | 8 | 9% |
| Student > Bachelor | 7 | 8% |
| Student > Master | 7 | 8% |
| Other | 17 | 19% |
| Unknown | 10 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 32 | 36% |
| Biochemistry, Genetics and Molecular Biology | 14 | 16% |
| Neuroscience | 14 | 16% |
| Medicine and Dentistry | 7 | 8% |
| Chemistry | 5 | 6% |
| Other | 5 | 6% |
| Unknown | 12 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 December 2017.
All research outputs
#5,240,151
of 25,373,627 outputs
Outputs from Neuron
#5,032
of 9,543 outputs
Outputs of similar age
#33,050
of 173,052 outputs
Outputs of similar age from Neuron
#44
of 97 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,543 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.2. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 173,052 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 97 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.