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Longitudinal change in dysarthria associated with Friedreich ataxia: a potential clinical endpoint

Overview of attention for article published in Journal of Neurology, June 2012
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Title
Longitudinal change in dysarthria associated with Friedreich ataxia: a potential clinical endpoint
Published in
Journal of Neurology, June 2012
DOI 10.1007/s00415-012-6547-x
Pubmed ID
Authors

Kristin M. Rosen, Joanne E. Folker, Adam P. Vogel, Louise A. Corben, Bruce E. Murdoch, Martin B. Delatycki

Abstract

CNS functions that show change across short periods of time are particularly useful clinical endpoints for Friedreich ataxia. This study determined whether there is measurable acoustical change in the dysarthria associated with Friedreich ataxia across yearly intervals. A total of 29 participants diagnosed with Friedreich ataxia were recorded across 4 years at yearly intervals. A repeated measures ANOVA was used to determine which acoustic measures differed across time, and pairwise t tests were used to assess the consistency of the change across the time intervals. The relationship between the identified measures with perceptual severity was assessed with stepwise regression. Significant longitudinal change was observed with four measures that relate to the utterance duration and spectral changes in utterances. The spectral measures consistently detected change across time intervals of two or more years. The four measures combined moderately predicted perceptual severity. Together, the results implicate longitudinal change in speaking rate and utterance duration. Changes in speech associated with Friedreich ataxia can be measured across intervals of 2 years and therefore show rich potential for monitoring disease progression and therapy outcomes.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 40 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 15%
Student > Master 6 15%
Student > Bachelor 4 10%
Student > Ph. D. Student 4 10%
Professor > Associate Professor 4 10%
Other 8 20%
Unknown 8 20%
Readers by discipline Count As %
Medicine and Dentistry 11 28%
Social Sciences 4 10%
Nursing and Health Professions 4 10%
Agricultural and Biological Sciences 3 8%
Neuroscience 2 5%
Other 6 15%
Unknown 10 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2012.
All research outputs
#15,245,883
of 22,668,244 outputs
Outputs from Journal of Neurology
#3,206
of 4,448 outputs
Outputs of similar age
#106,382
of 166,900 outputs
Outputs of similar age from Journal of Neurology
#30
of 48 outputs
Altmetric has tracked 22,668,244 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,448 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
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