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Antiviral activities of extracts and selected pure constituents of Ocimum basilicum

Overview of attention for article published in Clinical & Experimental Pharmacology & Physiology, September 2005
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#24 of 1,426)
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

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1 news outlet
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4 X users
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18 patents
facebook
1 Facebook page
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4 Wikipedia pages

Citations

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280 Dimensions

Readers on

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269 Mendeley
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Title
Antiviral activities of extracts and selected pure constituents of Ocimum basilicum
Published in
Clinical & Experimental Pharmacology & Physiology, September 2005
DOI 10.1111/j.1440-1681.2005.04270.x
Pubmed ID
Authors

Lien‐Chai Chiang, Lean‐Teik Ng, Pei‐Win Cheng, Win Chiang, Chun‐Ching Lin

Abstract

1. Ocimum basilicum (OB), also known as sweet basil, is a well known medicinal herb in traditional Chinese medicine preparations. In the present study, extracts and purified components of OB were used to identify possible antiviral activities against DNA viruses (herpes viruses (HSV), adenoviruses (ADV) and hepatitis B virus) and RNA viruses (coxsackievirus B1 (CVB1) and enterovirus 71 (EV71)). 2. The results show that crude aqueous and ethanolic extracts of OB and selected purified components, namely apigenin, linalool and ursolic acid, exhibit a broad spectrum of antiviral activity. Of these compounds, ursolic acid showed the strongest activity against HSV-1 (EC50 = 6.6 mg/L; selectivity index (SI) = 15.2), ADV-8 (EC50 = 4.2 mg/L; SI = 23.8), CVB1 (EC50 = 0.4 mg/L; SI = 251.3) and EV71 (EC50 = 0.5 mg/L; SI = 201), whereas apigenin showed the highest activity against HSV-2 (EC50 = 9.7 mg/L; SI = 6.2), ADV-3 (EC50 = 11.1 mg/L; SI = 5.4), hepatitis B surface antigen (EC50 = 7.1 mg/L; SI = 2.3) and hepatitis B e antigen (EC50 = 12.8 mg/L; SI = 1.3) and linalool showed strongest activity against AVD-II (EC50 = 16.9 mg/L; SI = 10.5). 3. No activity was noted for carvone, cineole, beta-caryophyllene, farnesol, fenchone, geraniol, beta-myrcene and alpha-thujone. 4. The action of ursolic acid against CVB1 and EV71 was found to occur during the infection process and the replication phase. 5. With SI values greater than 200, the potential use of ursolic acid for treating infection with CVB1 and EV71 merits further investigation.

X Demographics

X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 269 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Unknown 268 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 42 16%
Researcher 39 14%
Student > Ph. D. Student 28 10%
Student > Master 27 10%
Student > Postgraduate 14 5%
Other 40 15%
Unknown 79 29%
Readers by discipline Count As %
Agricultural and Biological Sciences 41 15%
Pharmacology, Toxicology and Pharmaceutical Science 33 12%
Biochemistry, Genetics and Molecular Biology 27 10%
Chemistry 19 7%
Medicine and Dentistry 17 6%
Other 41 15%
Unknown 91 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 32. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2023.
All research outputs
#1,225,644
of 25,371,288 outputs
Outputs from Clinical & Experimental Pharmacology & Physiology
#24
of 1,426 outputs
Outputs of similar age
#1,684
of 70,142 outputs
Outputs of similar age from Clinical & Experimental Pharmacology & Physiology
#1
of 8 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,426 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 70,142 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them