| Title |
Mechanisms of Respiratory Syncytial Virus Modulation of Airway Immune Responses
|
|---|---|
| Published in |
Current Allergy and Asthma Reports, June 2012
|
| DOI | 10.1007/s11882-012-0278-z |
| Pubmed ID | |
| Authors |
Matthew T. Lotz, R. Stokes Peebles |
| Abstract |
Respiratory syncytial virus (RSV) most often causes severe respiratory disease in the very young and the elderly. Acute disease can also cause exacerbations of asthma in any age group. Recent findings provide insight into how the innate and adaptive immune systems respond to RSV infection and provide preliminary evidence that these effects vary significantly by RSV strain and host. Components of cell signaling pathways that induce inflammatory cytokine expression during the innate immune response and alter epithelial cell polarity through activating transcription factors, namely NF-κB, are now more clearly understood. New studies also reveal how RSV infection skews T helper (Th) cell differentiation away from the cell-mediated Th1 subset and towards the Th2 subset. There are also new data supporting preferential Th17 differentiation during RSV infection. In addition, effective immune system regulation of IL-10 expression and T regulatory cell (Treg) airway accumulation are essential for effective RSV clearance. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Argentina | 1 | 17% |
| United States | 1 | 17% |
| Unknown | 4 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 67% |
| Scientists | 1 | 17% |
| Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 4% |
| Brazil | 2 | 2% |
| United Kingdom | 1 | 1% |
| Chile | 1 | 1% |
| Japan | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 90 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 22% |
| Student > Master | 19 | 19% |
| Student > Ph. D. Student | 18 | 18% |
| Student > Bachelor | 9 | 9% |
| Other | 6 | 6% |
| Other | 14 | 14% |
| Unknown | 12 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 27% |
| Agricultural and Biological Sciences | 25 | 25% |
| Biochemistry, Genetics and Molecular Biology | 11 | 11% |
| Immunology and Microbiology | 11 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Other | 4 | 4% |
| Unknown | 20 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 September 2012.
All research outputs
#13,363,429
of 22,668,244 outputs
Outputs from Current Allergy and Asthma Reports
#483
of 803 outputs
Outputs of similar age
#92,965
of 167,239 outputs
Outputs of similar age from Current Allergy and Asthma Reports
#11
of 17 outputs
Altmetric has tracked 22,668,244 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 803 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.9. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
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We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.