| Title |
Transcatheter Treatment of Hepatocellular Carcinoma with Doxorubicin-loaded DC Bead (DEBDOX): Technical Recommendations
|
|---|---|
| Published in |
CardioVascular and Interventional Radiology, October 2011
|
| DOI | 10.1007/s00270-011-0287-7 |
| Pubmed ID | |
| Authors |
Riccardo Lencioni, Thierry de Baere, Marta Burrel, James G. Caridi, Johannes Lammer, Katerina Malagari, Robert C. G. Martin, Elizabeth O’Grady, Maria Isabel Real, Thomas J. Vogl, Anthony Watkinson, Jean-Francois H. Geschwind |
| Abstract |
Tranarterial chemoembolization (TACE) has been established by a meta-analysis of randomized controlled trials as the standard of care for nonsurgical patients with large or multinodular noninvasive hepatocellular carcinoma (HCC) isolated to the liver and with preserved liver function. Although conventional TACE with administration of an anticancer-in-oil emulsion followed by embolic agents has been the most popular technique, the introduction of embolic drug-eluting beads has provided an alternative to lipiodol-based regimens. Experimental studies have shown that TACE with drug-eluting beads has a safe pharmacokinetic profile and results in effective tumor killing in animal models. Early clinical experiences have confirmed that drug-eluting beads provide a combined ischemic and cytotoxic effect locally with low systemic toxic exposure. Recently, the clinical value of a TACE protocol performed by using the embolic microsphere DC Bead loaded with doxorubicin (DEBDOX; drug-eluting bead doxorubicin) has been shown by randomized controlled trials. An important limitation of conventional TACE has been the inconsistency in the technique and the treatment schedules. This limitation has hampered the acceptance of TACE as a standard oncology treatment. Doxorubicin-loaded DC Bead provides levels of consistency and repeatability not available with conventional TACE and offers the opportunity to implement a standardized approach to HCC treatment. With this in mind, a panel of physicians took part in a consensus meeting held during the European Conference on Interventional Oncology in Florence, Italy, to develop a set of technical recommendations for the use of DEBDOX in HCC treatment. The conclusions of the expert panel are summarized. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 3 | 38% |
| United States | 1 | 13% |
| Unknown | 4 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 88% |
| Science communicators (journalists, bloggers, editors) | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 143 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| Spain | 2 | 1% |
| Japan | 2 | 1% |
| India | 1 | <1% |
| Germany | 1 | <1% |
| France | 1 | <1% |
| Unknown | 133 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 20 | 14% |
| Researcher | 19 | 13% |
| Other | 17 | 12% |
| Student > Ph. D. Student | 15 | 10% |
| Student > Postgraduate | 15 | 10% |
| Other | 38 | 27% |
| Unknown | 19 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 95 | 66% |
| Nursing and Health Professions | 4 | 3% |
| Chemistry | 4 | 3% |
| Engineering | 4 | 3% |
| Agricultural and Biological Sciences | 3 | 2% |
| Other | 12 | 8% |
| Unknown | 21 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 March 2022.
All research outputs
#7,144,201
of 23,330,477 outputs
Outputs from CardioVascular and Interventional Radiology
#579
of 2,423 outputs
Outputs of similar age
#43,258
of 140,741 outputs
Outputs of similar age from CardioVascular and Interventional Radiology
#4
of 8 outputs
Altmetric has tracked 23,330,477 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 2,423 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 140,741 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.