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Immunohistochemical investigation of cell cycle and apoptosis regulators (Survivin, β-Catenin, P53, Caspase 3) in canine appendicular osteosarcoma

Overview of attention for article published in BMC Veterinary Research, June 2012
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Title
Immunohistochemical investigation of cell cycle and apoptosis regulators (Survivin, β-Catenin, P53, Caspase 3) in canine appendicular osteosarcoma
Published in
BMC Veterinary Research, June 2012
DOI 10.1186/1746-6148-8-78
Pubmed ID
Authors

Laura Bongiovanni, Francesca Mazzocchetti, Daniela Malatesta, Mariarita Romanucci, Andrea Ciccarelli, Paolo Buracco, Raffaella De Maria, Chiara Palmieri, Marina Martano, Emanuela Morello, Lorella Maniscalco, Leonardo Della Salda

Abstract

Osteosarcoma (OSA) represents the most common canine primary bone tumour. Despite several pathways have been investigated so far, few molecules have been identified as prognostic tools or potential therapeutic targets, and there is still the need to find out molecular pathways with specific influence over OSA progression to facilitate earlier prognosis and treatment.Aims of the present study were to evaluate the immunohistochemical pattern and levels of expression of a panel of molecules (survivin, β-catenin, caspase 3 -inactive and active forms- and p53) involved in cell cycle and apoptosis regulation in canine OSA samples, known to be of interest in the study also of human OSA, and to detect specific relations among them and with histological tumour grade, disease free interval (DFI) and overall survival (OS).

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 53 98%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 8 15%
Student > Master 8 15%
Researcher 7 13%
Other 7 13%
Professor > Associate Professor 5 9%
Other 13 24%
Unknown 6 11%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 26 48%
Medicine and Dentistry 11 20%
Engineering 2 4%
Computer Science 1 2%
Biochemistry, Genetics and Molecular Biology 1 2%
Other 2 4%
Unknown 11 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2012.
All research outputs
#14,728,447
of 22,668,244 outputs
Outputs from BMC Veterinary Research
#1,237
of 3,031 outputs
Outputs of similar age
#103,620
of 167,349 outputs
Outputs of similar age from BMC Veterinary Research
#18
of 38 outputs
Altmetric has tracked 22,668,244 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,031 research outputs from this source. They receive a mean Attention Score of 3.8. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 167,349 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.