Title |
β-Arrestin prevents cell apoptosis through pro-apoptotic ERK1/2 and p38 MAPKs and anti-apoptotic Akt pathways
|
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Published in |
Apoptosis, June 2012
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DOI | 10.1007/s10495-012-0741-2 |
Pubmed ID | |
Authors |
Xiaohua Yang, Gengyin Zhou, Tao Ren, Hui Li, Yanjun Zhang, Deling Yin, Haixin Qian, Qinchuan Li |
Abstract |
Our previous studies have shown that β-arrestin 2 plays an anti-apoptotic effect. However, the mechanisms by which β-arrestin contribute to anti-apoptotic role remain unclear. In this study, we show that a deficiency of either β-arrestin 1 or β-arrestin 2 significantly increases serum deprivation (SD)-induced percentage of apoptotic cells. β-arrestin 2 deficient-induced apoptosis was inhibited by transfection with β-arrestin 2 full-length plasmid, revealing that SD-induced apoptosis is dependent on β-arrestin 2. Furthermore, in the absence of either β-arrestin 1 or β-arrestin 2 significantly enhances SD-induced the level of pro-apoptotic proteins, including cleaved caspase-3, extracellular-signal regulated kinase 1/2 (ERK1/2) and p38, members of mitogen-activated protein kinases (MAPKs). In addition, a deficiency of either β-arrestin 1 or β-arrestin 2 inhibits phosphorylation of Akt. The SD-induced changes in cleaved caspase-3, ERK1/2 and p38 MAPKs, Akt, and apoptotic cell numbers could be blocked by double knockout of β-arrestin 1/2. Our study thus demonstrates that β-arrestin inhibits cell apoptosis through pro-apoptotic ERK1/2 and p38 MAPKs and anti-apoptotic Akt signaling pathways. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 5% |
Unknown | 20 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 5 | 24% |
Student > Ph. D. Student | 5 | 24% |
Student > Bachelor | 3 | 14% |
Professor > Associate Professor | 3 | 14% |
Researcher | 2 | 10% |
Other | 2 | 10% |
Unknown | 1 | 5% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 13 | 62% |
Biochemistry, Genetics and Molecular Biology | 4 | 19% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
Psychology | 1 | 5% |
Medicine and Dentistry | 1 | 5% |
Other | 0 | 0% |
Unknown | 1 | 5% |