Title |
Celiac disease in subjects with type 1 diabetes mellitus: a prevalence study in western Sicily (Italy)
|
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Published in |
Endocrine, June 2012
|
DOI | 10.1007/s12020-012-9718-8 |
Pubmed ID | |
Authors |
Domenico Greco, Maria Pisciotta, Francesco Gambina, Filippo Maggio |
Abstract |
The association between celiac disease and type 1 diabetes mellitus is well known. Up to now, celiac disease prevalence in children and adults with type 1 diabetes in Sicily has not been reported. The aim of this study was to assess the prevalence of celiac disease in patients with type 1 diabetes mellitus who come from a defined geographical area in western Sicily and to investigate the clinical features of these subjects. The records of 492 consecutive patients with type 1 diabetes mellitus referred in a period of 5 years were analyzed. During the period of the survey, out of 492 patients with type 1 diabetes, 22 (4.5 %) had a previous diagnosis of celiac disease. There were 14 females and 8 males; these patients showed a mean age of 13 years at diabetes onset. Diagnosis of celiac disease was often simultaneous or subsequent to that of diabetes. Autoimmune thyroiditis was coexisting in 8 patients (36 %). Our data confirm, in a Sicilian population, the not unusual association between celiac disease and type 1 diabetes, although prevalence rate is lower than in others Italian studies. Autoimmune thyroiditis is present with high prevalence in these patients. Celiac disease diagnosis often followed onset of type 1 diabetes, particularly in female subjects with a young age at diabetes onset; therefore, in these subjects, an active search for the presence of celiac disease is warranted for many years after appearance of diabetes. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 52 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 10 | 19% |
Researcher | 9 | 17% |
Student > Postgraduate | 5 | 10% |
Student > Doctoral Student | 4 | 8% |
Student > Ph. D. Student | 3 | 6% |
Other | 11 | 21% |
Unknown | 10 | 19% |
Readers by discipline | Count | As % |
---|---|---|
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Agricultural and Biological Sciences | 4 | 8% |
Biochemistry, Genetics and Molecular Biology | 4 | 8% |
Unspecified | 2 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 5 | 10% |
Unknown | 12 | 23% |