Title |
Gastrointestinal Pathology in Celiac Disease
|
---|---|
Published in |
American Journal of Clinical Pathology, July 2012
|
DOI | 10.1309/ajcpe89zpvjtspwl |
Pubmed ID | |
Authors |
Ian S. Brown, Jason Smith, Christophe Rosty |
Abstract |
The main histologic feature of celiac disease is increased intraepithelial lymphocytes (IELs) with or without villous atrophy of the duodenal mucosa. The aim of this study was to document a broad range of additional morphologic changes in intestinal mucosa biopsy specimens from patients with celiac disease. Our cohort comprised 150 patients with positive tissue transglutaminase serologic findings; 7 were at Corazza stage A1, 58 at stage B1, and 85 at stage B2. IEL counts per 100 epithelial cells ranged from 34 to 156 (mean, 88.6); a significant neutrophilic infiltrate was present in 85 cases (56.7%); eosinophil count ranged from 3 to 50 per high-power field (mean, 14.6). Additional findings included morphologic changes in enterocytes in 68.7%, subepithelial collagen thickening in 45.3%, and associated lymphocytic gastritis in 30.4% of patients. We demonstrated that these underrecognized features, which can be misleading, are not uncommon in celiac disease and were positively associated with more advanced stages of the disease (P < .0001). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 25% |
United States | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 50% |
Scientists | 1 | 25% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Germany | 1 | 2% |
Canada | 1 | 2% |
Unknown | 53 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 10 | 18% |
Researcher | 8 | 14% |
Student > Ph. D. Student | 8 | 14% |
Other | 6 | 11% |
Student > Master | 6 | 11% |
Other | 12 | 21% |
Unknown | 6 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 29 | 52% |
Biochemistry, Genetics and Molecular Biology | 7 | 13% |
Agricultural and Biological Sciences | 4 | 7% |
Immunology and Microbiology | 3 | 5% |
Engineering | 2 | 4% |
Other | 1 | 2% |
Unknown | 10 | 18% |