| Title |
Folic acid supplementation, MTHFR and MTRR polymorphisms, and the risk of childhood leukemia: the ESCALE study (SFCE)
|
|---|---|
| Published in |
Cancer Causes & Control, June 2012
|
| DOI | 10.1007/s10552-012-0004-0 |
| Pubmed ID | |
| Authors |
Alicia Amigou, Jérémie Rudant, Laurent Orsi, Stéphanie Goujon-Bellec, Guy Leverger, André Baruchel, Yves Bertrand, Brigitte Nelken, Geneviève Plat, Gérard Michel, Stéphanie Haouy, Pascal Chastagner, Stéphane Ducassou, Xavier Rialland, Denis Hémon, Jacqueline Clavel |
| Abstract |
Fetal folate deficiency may increase the risk of subsequent childhood acute leukemia (AL), since folates are required for DNA methylation, synthesis, and repair, but the literature remains scarce. This study tested the hypothesis that maternal folic acid supplementation before or during pregnancy reduces AL risk, accounting for the SNPs rs1801133 (C677T) and rs1801131 (A1298C) in MTHFR and rs1801394 (A66G) and rs1532268 (C524T) in MTRR, assumed to modify folate metabolism. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 2% |
| Switzerland | 1 | 2% |
| Unknown | 63 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 12 | 18% |
| Researcher | 11 | 17% |
| Student > Master | 9 | 14% |
| Student > Ph. D. Student | 5 | 8% |
| Student > Doctoral Student | 5 | 8% |
| Other | 15 | 23% |
| Unknown | 8 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 22 | 34% |
| Nursing and Health Professions | 11 | 17% |
| Agricultural and Biological Sciences | 7 | 11% |
| Biochemistry, Genetics and Molecular Biology | 5 | 8% |
| Social Sciences | 5 | 8% |
| Other | 4 | 6% |
| Unknown | 11 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 January 2020.
All research outputs
#6,286,436
of 23,957,285 outputs
Outputs from Cancer Causes & Control
#750
of 2,189 outputs
Outputs of similar age
#37,860
of 149,739 outputs
Outputs of similar age from Cancer Causes & Control
#14
of 40 outputs
Altmetric has tracked 23,957,285 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 2,189 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.3. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 149,739 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.